Auflistung nach Autor "Bartkuhn, Marek"
Anzeige der Dokumente 1-15 von 15
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Deciphering the Notch Pathway: A Bioinformatics Analysis of the RBPJ/Notch Axis
Friedrich, Tobias (2023)Notch-mediated signal transduction plays a pivotal role for multiple biological processes in development, differentiation and cell homeostasis. Its dysregulation has been linked to several diseases, including different ... -
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
Günther, Katharina; Rust, Mareike; Leers, Joerg; Boettger, Thomas; Scharfe, Maren; Jarek, Michael; Bartkuhn, Marek; Renkawitz, Rainer (2013)The heterogeneous collection of nucleosome remodelling and deacetylation (NuRD) complexes can be grouped into the MBD2- or MBD3-containing complexes MBD2 NuRD and MBD3 NuRD. MBD2 is known to bind to methylated CpG sequences ... -
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
Günther, Katharina; Rust, Mareike; Leers, Joerg; Boettger, Thomas; Scharfe, Maren; Jarek, Michael; Bartkuhn, Marek; Renkawitz, Rainer (2013)The heterogeneous collection of nucleosome remodelling and deacetylation (NuRD) complexes can be grouped into the MBD2- or MBD3-containing complexes MBD2 NuRD and MBD3 NuRD. MBD2 is known to bind to methylated CpG sequences ... -
Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner
Weiterer, Sinah-Sophia; Meier-Soelch, Johanna; Georgomanolis, Theodore; Mizi, Athanasia; Beyerlein, Anna; Weiser, Hendrik; Brant, Lilija; Mayr-Buro, Christin; Jurida, Liane; Beuerlein, Knut; Müller, Helmut; Weber, Axel; Tenekeci, Ulas; Dittrich-Breiholz, Oliver; Bartkuhn, Marek; Nist, Andrea; Stiewe, Thorsten; IJcken, Wilfred FJ; Riedlinger, Tabea; Schmitz, M Lienhard; Papantonis, Argyris; Kracht, Michael (2020) -
Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
Kiehl, Steffen; Zimmermann, Tobias; Savai, Rajkumar; Pullamsetti, Soni S.; Seeger, Werner; Bartkuhn, Marek; Dammann, Reinhard H. (2017)Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. ... -
Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function
Deutschmeyer, Verena; Breuer, Janina; Walesch, Sara K.; Sokol, Anna M.; Graumann, Johannes; Bartkuhn, Marek; Boettger, Thomas; Rossbach, Oliver; Richter, Antje M. (2019) -
From human monocytes to genome-wide binding sites : a protocol for small amounts of blood: Monocyte Isolation/ChIP-Protocol/Library Amplification/Genome Wide Computational Data Analysis
Weiterer, Sebastian; Uhle, Florian; Bhuju, Sabin; Jarek, Michael; Weigand, Markus A.; Bartkuhn, Marek (2014)Chromatin immunoprecipitation in combination with a genome-wide analysis via high-throughput sequencing is the state of the art method to gain genome-wide representation of histone modification or transcription factor ... -
Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
Ferrante, Francesca; Giaimo, Benedetto Daniele; Friedrich, Tobias; Sugino, Toshiya; Mertens, Daniel; Kugler, Sabrina; Gahr, Bernd Martin; Just, Steffen; Pan, Leiling; Bartkuhn, Marek; Potente, Michael; Oswald, Franz; Borggrefe, Tilman (2022) -
Identification and modelling of genetic features for genomic position profiling to support future approaches in gene therapy
Menzel, Michael (2021-05)Genetic variability and mutations are a fundamental necessity for living organisms. In the context of evolution, both factors facilitate survival and enable the adaption of life to the environment. However, genetic variability ... -
JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions
Procida, Tara; Friedrich, Tobias; Jack, Antonia P. M.; Peritore, Martina; Bönisch, Clemens; Eberl, Hans Christian; Daus, Nadine; Kletenkov, Konstantin; Nist, Andrea; Stiewe, Thorsten; Borggrefe, Tilman; Mann, Matthias; Bartkuhn, Marek; Hake, Sandra B. (2021) -
Konzeptionierung und Entwicklung eines Metadatenrepositoriums zur Exploration des klinischen Datenbestandes in Forschung und Routine
Eberhardt, Florian (2023)Die Medizininformatik-Initiative in Deutschland verdeutlicht den Bedarf an offenen und standardisierten Datenstrukturen sowie die Zusammenführung von Datenbereichen aus der medizinischen Forschung und der klinischen ... -
Notch-dependent and -independent functions of transcription factor RBPJ
Friedrich, Tobias; Ferrante, Francesca; Pioger, Léo; Nist, Andrea; Stiewe, Thorsten; Andrau, Jean-Christophe; Bartkuhn, Marek; Giaimo, Benedetto Daniele; Borggrefe, Tilman (2022) -
Ribonuclease E strongly impacts bacterial adaptation to different growth conditions
Börner, Janek; Friedrich, Tobias; Bartkuhn, Marek; Klug, Gabriele (2023)Adaptation of bacteria to changes in their environment is often accomplished by changes of the transcriptome. While we learned a lot on the impact of transcriptional regulation in bacterial adaptation over the last decades, ... -
Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis
Töpfer, Uwe; Bischoff, Maik C.; Bartkuhn, Marek; Holz, Anne (2019) -
The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs
Herchenröther, Andreas; Gossen, Stefanie; Friedrich, Tobias; Reim, Alexander; Daus, Nadine; Diegmüller, Felix; Leers, Jörg; Sani, Hakimeh Moghaddas; Gerstner, Sarah; Schwarz, Leah; Stellmacher, Inga; Szymkowiak, Laura Victoria; Nist, Andrea; Stiewe, Thorsten; Borggrefe, Tilman; Mann, Matthias; Mackay, Joel P.; Bartkuhn, Marek; Borchers, Annette; Lan, Jie; Hake, Sandra B. (2023)Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as a direct histone variant H2A.Z interactor involved in mitosis and craniofacial development. ...