Auflistung nach Autor "Dammann, Reinhard"
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Characterization and validation of postnatal murine precision cut lung slices using different approaches of stereology
Pérez Bravo, David (2022)Understanding the process of alveolarization is necessary, since it is key to develop new therapeutic strategies for pulmonary structural diseases. Unfortunately, in vivo approaches in mice often lead to lethal phenotypes ... -
Efficacy of Fibroblast Growth Factor Receptor (FGFR) inhibitor Infigratinib on Experimental Autoimmune Encephalomyelitis (EAE), a mouse model of Multiple sclerosis (MS)
Rajendran, Vinothkumar (2021)Multiple sclerosis (MS) is associated with oligodendrocytes damage resulting in demyelination, failure of remyelination and functional loss of neurons. Present therapeutic disease modifying drugs for MS are acting predominantly ... -
Enhanced H3K4me3 demethylation by inhibition of fatty acid oxidation enables heart regeneration in adult mice
Li, Xiang (2021)During early postnatal heart development, the metabolic profile switches from glycolysis to fatty acid oxidation (FAO). At the same time, cardiomyocytes (CM) undergo profound maturation characterized by hypertrophic growth, ... -
Funktionelle Analyse von miR-1/206/133 in der Skelettmuskulatur von Mus musculus
Klockner, Ina (2021-07)Die Kontrolle von Genaktivität erfolgt auf transkriptioneller, epigenetischer, sowie auf posttranskriptioneller Ebene. Eine signifikante Rolle im komplexen Netzwerk der Genregulation spielen kleine nicht-kodierende ... -
Human circular RNAs: design, development and functional analysis of protein sponges
Nuthalapati, Stephen Sukumar (2022)Circular RNAs (circRNAs) are a relatively new class of stable, non-coding RNAs often derived from protein-coding genes. They are generated by the so-called backsplicing mechanism, whereby one single or several adjacent ... -
Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican
Brunn, David Alexander (2021)Lung cancer is the leading cause of cancer-related death worldwide and accounts for more than 1.8 million deaths per year globally. It has been shown that the tumour microenvironment plays a crucial role in tumour progression ... -
Long non-coding RNA ADPGK-AS1 regulates mitochondrial and metabolic remodeling in macrophages and influences tumor progression
Karger, Annika Michaela Magdalena (2022)Recent immunometabolism studies have shown that alterations in the metabolic profile of macrophages determine the macrophage phenotype and function. Long non-coding RNAs (lncRNAs) regulate macrophage activation and ... -
Origin and fate of vascular smooth muscle cells during vascular remodeling and reverse remodeling in pulmonary hypertension
Chu, Xuran (2022)Pulmonary hypertension occurs when the pressure in the blood vessels leading from the heart to the lungs is too high. During pulmonary hypertension, the blood vessels in the lungs develop an increased amount of smooth ... -
Synergistic targeting of ovarian cancer cells through simultaneous inhibition of key metabolic enzymes
Dreute, Jan (2023-07)Despite advances in the therapy of high-grade serous ovarian cancer, overall survival rates remain stagnant, highlighting the need for innovative treatment strategies. In the present study, immortalized fallopian tube ... -
The role of miR-135b in normal and aberrant late lung development
Nardiello, Claudio (2020)Bronchopulmonary dysplasia (BPD) is a chronic lung disease that occurs in premature infants. BPD is a consequence of oxygen supplementation and/or mechanical ventilation and is characterized by fewer, larger alveoli and ... -
The role of the homeobox transcription factor Duxbl in rhabdomyosarcoma formation
Zhong, Jiasheng (2021)Skeletal muscles exhibit a remarkable regeneration capacity that is mediated by resident muscle stem cells (MuSCs). While normally quiescent they become activated upon injury, proliferate and differentiate into myofibers ...