Auflistung nach Autor "Hackstein, Holger"
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Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees
Sluzalska, Katarzyna D.; Liebisch, Gerhard; Wilhelm, Jochen; Ishaque, Bernd; Hackstein, Holger; Schmitz, Gerd; Rickert, Markus; Steinmeyer, Juergen (2017)Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to determine the effects of ... -
Identifizierung neuer Oberflächenmarker auf mesenchymalen Stromazellen aus dem Knochenmark
Hemmer, Svenja (2021)Mesenchymale Stammzellen (MSC) werden als nicht-hämatopoetische, plastikadhärente, sich selbst erneuernde Zellen definiert. Sie sind in der Lage, sich in Fett, Knochen und Knorpel zu differenzieren und besitzen vielfältige ... -
Modulation of respiratory dendritic cells during Klebsiella pneumonia infection
Hackstein, Holger; Kranz, Sabine; Lippitsch, Anne; Wachtendorf, Andreas; Kershaw, Olivia; Gruber, Achim D; Michel, Gabriela; Lohmeyer, Jürgen; Bein, Gregor; Baal, Nelli; Herold, Susanne (2013)Background: Klebsiella pneumoniae is a leading cause of severe hospital-acquired respiratory tract infections anddeath but little is known regarding the modulation of respiratory dendritic cell (DC) subsets. Plasmacytoid ... -
Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival
Hackstein, Holger; Lippitsch, Anne; Krug, Philipp; Schevtschenko, Inna; Kranz, Sabine; Hecker, Matthias; Dietert, Kristina; Gruber, Achim D.; Bein, Gregor; Brendel, Cornelia; Baal, Nelli (2015)Background: Numerous studies have described the immunosuppressive capacity of mesenchymal stem cells (MSC) but these studies use mixtures of heterogeneous progenitor cells for in vitro expansion. Recently, multipotent MSC ... -
The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth
Jiménez, Adriana P.; Traum, Annalena; Boettger, Thomas; Hackstein, Holger; Richter, Antje M.; Dammann, Reinhard H. (2017)The Hippo pathway regulates organ size, growth and comprises several tumor related factors, including the oncoprotein YAP1 and the tumor suppressor RASSF1A. RASSF1A is frequently epigenetically inactivated in cancer. In ...