Auflistung nach Autor "Quack, Thomas"
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Arylmethylamino steroids as antiparasitic agents
Krieg, Reimar; Jortzik, Esther; Goetz, Alice-Anne; Blandin, Stéphanie; Wittlin, Sergio; Elhabiri, Mourad; Rahbari, Mahsa; Nuryyeva, Selbi; Voigt, Kerstin; Dahse, Hans-Martin; Brakhage, Axel; Beckmann, Svenja; Quack, Thomas; Grevelding, Christoph G.; Pinkerton, Anthony B.; Schönecker, Bruno; Burrows, Jeremy; Davioud-Charvet, Elisabeth; Rahlfs, Stefan; Becker, Katja (2017)In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic ... -
Changes in the lipid profile of hamster liver after Schistosoma mansoni infection, characterized by mass spectrometry imaging and LC–MS/MS analysis
Wiedemann, Katja R.; Peter Ventura, Alejandra; Gerbig, Stefanie; Roderfeld, Martin; Quack, Thomas; Grevelding, Christoph G.; Roeb, Elke; Spengler, Bernhard (2022) -
Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs
Hahnel, Steffen; Quack, Thomas; Parker-Manuel, Sophie J.; Lu, Zhigang; Vanderstraete, Mathieu; Morel, Marion; Dissous, Colette; Cailliau, Katia; Grevelding, Christoph G (2014)In the search for new strategies to fight schistosomiasis, the unique reproductive biology of Schistosoma mansoni has come into the focus of research. The development of the gonads and the ability of egg production are ... -
Metabolic reprogramming of hepatocytes by Schistosoma mansoni eggs
von Bülow, Verena; Gindner, Sarah; Baier, Anne; Hehr, Laura; Buss, Nicola; Russ, Lena; Wrobel, Sarah; Wirth, Victoria; Tabatabai, Kuscha; Quack, Thomas; Haeberlein, Simone; Kadesch, Patrik; Gerbig, Stefanie; Wiedemann, Katja R.; Spengler, Bernhard; Mehl, Annabel; Morlock, Gertrud; Schramm, Gabriele; Pons-Kühnemann, Jörn; Falcone, Franco H.; Wilson, R. Alan; Bankov, Katrin; Wild, Peter; Grevelding, Christoph G.; Roeb, Elke; Roderfeld, Martin (2023)Background & Aims: Schistosomiasis is a parasitic infection which affects more than 200 million people globally. Schistosome eggs, but not the adult worms, are mainly responsible for schistosomiasis-specific morbidity in ... -
Schistosoma mansoni eggs induce Wnt/ß-catenin signaling and activate the protooncogene c-Jun in human and hamster colon
Weglage, Jakob; Wolters, Friederike; Hehr, Laura; Lichtenberger, Jakob; Wulz, Celina; Hempel, Felix; Baier, Anne; Quack, Thomas; Köhler, Kernt; Longerich, Thomas; Schramm, Gabriele; Irungbam, Karuna; Mueller, Heike; Bülow, Verena von; Tschuschner, Annette; Odenthal, Margarete; Drebber, Uta; Arousy, Maha El; Ramalho, Leandra N. Z.; Bankov, Katrin; Wild, Peter; Pons-Kühnemann, Jörn; Tschammer, Jonas; Grevelding, Christoph; Roeb, Elke; Roderfeld, Martin (2020) -
Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging
Kadesch, Patrik; Quack, Thomas; Gerbig, Stefanie; Grevelding, Christoph; Spengler, Bernhard (2020) -
Whole-organ isolation approach as a basis for tissue-specific analyses in Schistosoma mansoni
Hahnel, Steffen; Lu, Zhigang; Wilson, R. Alan; Grevelding, Christoph G.; Quack, Thomas (2013)As a neglected disease, schistosomiasis is still an enormous problem in the tropics and subtropics. Since the 1980s, Praziquantel (PZQ) has been the drug of choice but can be anticipated to lose efficacy in the future due ...