Auflistung nach Autor "Savai, Rajkumar"
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ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth
Kiehl, Steffen; Herkt, Stefanie C.; Richter, Antje M.; Fuhrmann, Liesa; El-Nikhely, Nefertiti; Seeger, Werner; Savai, Rajkumar; Dammann, Reinhard H. (2014)Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a ... -
Classification and mapping of tumour-infiltrating lymphocytes (TILs) in lung adenocarcinoma and lung squamous cell carcinoma
Hadjinicolaou, Constantinos (2019)Lung cancer is the most frequent and one of the deadliest types of cancer. The goal of this study was to determine the type of tumour-infiltrating lymphocytes, map them and show which types of lymphocytes predominate in ... -
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice
Hempel, Felix; Roderfeld, Martin; Savai, Rajkumar; Sydykov, Akylbek; Irungbam, Karuna; Schermuly, Ralph; Voswinckel, Robert; Köhler, Kernt; Churin, Yury; Kiss, Ladislau; Bier, Jens; Pons-Kühnemann, Jörn; Roeb, Elke (2019) -
Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer
Kiehl, Steffen; Zimmermann, Tobias; Savai, Rajkumar; Pullamsetti, Soni S.; Seeger, Werner; Bartkuhn, Marek; Dammann, Reinhard H. (2017)Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. ... -
Establishment of mouse lung tumor models and development of new therapeutic approaches
Savai, Rajkumar (2005)Two mouse models of lung cancer were used to investigate cancer progression, cancer treatment, and cancer imaging. One model was established by subcutaneous injection of human adenocarcinoma A549 cells and lewis lung ... -
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
Weigert, Andreas; Zheng, Xiang; Nenzel, Alina; Turkowski, Kati; Günther, Stefan; Strack, Elisabeth; Sirait-Fischer, Evelyn; Elwakeel, Eiman; Kur, Ivan M.; Nikam, Vandana S.; Valasarajan, Chanil; Winter, Hauke; Wissgott, Alexander; Voswinkel, Robert; Grimminger, Friedrich; Brüne, Bernhard; Seeger, Werner; Pullamsetti, Soni Savai; Savai, Rajkumar (2022)Fibrocytes are bone marrow–derived monocytic cells implicated in wound healing. Here, we identify their role in lung cancer progression/ metastasis. Selective manipulation of fibrocytes in mouse lung tumor models documents ... -
Long non-coding RNA ADPGK-AS1 regulates mitochondrial and metabolic remodeling in macrophages and influences tumor progression
Karger, Annika Michaela Magdalena (2022)Recent immunometabolism studies have shown that alterations in the metabolic profile of macrophages determine the macrophage phenotype and function. Long non-coding RNAs (lncRNAs) regulate macrophage activation and ... -
Reprogramming of tumor-associated macrophages by targeting β-catenin-FOSL2-ARID5A signaling – novel treatment of lung cancer
Sarode, Poonam Ashwin Kumar (2020)Lungenkrebs wird als der verheerenste Krebstyp angesehen, wegen seiner weiten Verbreitung, erniedrigten Lebensqualität, oft erst späten Diagnose und nicht zuletzt wegen der niedrigen Anschlagsquote, hohen Toxizität und ... -
Die Rolle der FGF14-Expression bei den Zelllinien Nicht-Kleinzelliger-Lungenkarzinome
Herzberg, Frederik (2023)Für den Zeitraum 2016-2018 betrug die relative 5-Jahres-Überlebensrate Lungenkrebserkrankter in Deutschland bei Frauen 22% und bei Männern 17%. Lungenkarzinome werden in die zwei Hauptgruppen SCLC und NSCLC unterteilt. Als ... -
Spatial density and distribution of tumor-associated macrophages predict survival in non–small cell lung carcinoma
Zheng, Xiang (2021)The respective antitumoral and protumoral roles of M1 and M2 tumor-associated macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer, density and topology of distinct TAM phenotypes at the ...