Browsing by Author "Valasarajan, Chanil"
Now showing items 1-2 of 2
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Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
Weigert, Andreas; Zheng, Xiang; Nenzel, Alina; Turkowski, Kati; Günther, Stefan; Strack, Elisabeth; Sirait-Fischer, Evelyn; Elwakeel, Eiman; Kur, Ivan M.; Nikam, Vandana S.; Valasarajan, Chanil; Winter, Hauke; Wissgott, Alexander; Voswinkel, Robert; Grimminger, Friedrich; Brüne, Bernhard; Seeger, Werner; Pullamsetti, Soni Savai; Savai, Rajkumar (2022)Fibrocytes are bone marrow–derived monocytic cells implicated in wound healing. Here, we identify their role in lung cancer progression/ metastasis. Selective manipulation of fibrocytes in mouse lung tumor models documents ... -
Identification of ADORA1-PDE10A Complex Formation and Its Bidirectional Regulation of Intracellular Cyclic AMP Levels as a Novel Therapeutic Target for Treating Pulmonary Hypertension
Valasarajan, Chanil (2020)Despite substantial advancements in the treatment of pulmonary arterial hypertension (PAH), obstacles still remain in achieving the optimal outcomes. Various treatments have been developed to target signaling pathways ...