Browsing by Author "Yanik, Mert"

Now showing items 1-3 of 3

    • Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments 

      Yanik, Mert; Ponnam, Surya Prakash Goud; Wimmer, Tobias; Trimborn, Lennart; Müller, Carina; Gambert, Isabel; Ginsberg, Johanna; Janise, Annabella; Domicke, Janina; Wende, Wolfgang; Lorenz, Birgit; Stieger, Knut (2018)
      Common genome-editing strategies are either based on non-homologous end joining (NHEJ) or, in the presence of a template DNA, based on homologous recombination with long (homology-directed repair [HDR]) or short ...

    • Generierung hochspezifischer Nukleasen für die zielgerichtete Spaltung genomischer DNA-Sequenzen 

      Yanik, Mert (2013)
      Hochspezifische Nukleasen haben sich im Bereich gene targeting und gene therapy zu unentbehrlichen Werkzeugen entwickelt. Eine auf Zufall basierte Integration von DNA-Sequenzen ins Genom verschiedener Organismen mit den ...

    • TALE-PvuII fusion proteins : Novel tools for gene targeting 

      Yanik, Mert; Alzubi, Jamal; Lahaye, Thomas; Cathomen, Toni; Pingoud, Alfred; Wende, Wolfgang (2013)
      Zinc finger nucleases (ZFNs) consist of zinc fingers as DNA-binding module and the non-specific DNA-cleavage domain of the restriction endonuclease FokI as DNA-cleavage module. This architecture is also used by TALE nucleases ...