Evaluation of the fibroblast growth factor receptor 1 (FGFR1) in experimental autoimmune encephalomyelitis (EAE)
| dc.contributor.author | Rajendran, Ranjithkumar | |
| dc.date.accessioned | 2023-03-03T14:44:28Z | |
| dc.date.available | 2015-02-26T12:21:03Z | |
| dc.date.available | 2023-03-03T14:44:28Z | |
| dc.date.issued | 2014 | |
| dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-113581 | |
| dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/10939 | |
| dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-10322 | |
| dc.description.abstract | Fibroblast growth factors (FGFs) exert diverse biological effects by binding and activation of specific fibroblast growth factor receptors (FGFRs). Recent studies on the function of FGF2 in MOG35-55-induced experimental autoimmune encephalitis (EAE) showed that systemic deletion of FGF2 leads to a more severe disease course, increased lymphocyte and macrophage infiltration and decreased remyelination. In the present study the in vivo function of the corresponding receptor Fgfr1 was characterized using an oligodendrocyte-specific genetic approach. Plp/CreERT:Fgfr1fl/fl mice were administered tamoxifen to induce conditional Fgfr1 deletion in oligodendrocytes (referred to as Fgfr1ind-/-). In MOG35-55-induced EAE the Fgfr1ind-/- mice show a delayed onset of disease, less maximum disease severity and enhanced recovery. Decreased lymphocyte and macrophage/microglia infiltration, and myelin and axon degeneration are found in Fgfr1ind-/- mice. In acute EAE downregulation of proinflammatory cytokines such as TNF-alpha, IL-1beta and IL-6, in chronic EAE downregulation of the CX3CL1/CX3CR1 pathway is seen in Fgfr1ind-/- mice. Furthermore, increased expression of BDNF, TrkB (neurotrophic tyrosine kinase receptor, type 2) and decreased expression of Lingo-1 are found in Fgfr1ind-/- mice. Fgfr1 ablation in oligodendrocytes showed increased TrkB expression in whole lysate of cortex and spinal cord. These data suggest that impaired signalling via oligodendroglial Fgfr1 has a beneficial effect on MOG35-55-induced EAE. These findings on the oligodendroglial Fgfr1 pathway may offer a new target for developing therapy in multiple sclerosis. | en |
| dc.language.iso | en | de_DE |
| dc.rights | In Copyright | * |
| dc.rights.uri | http://rightsstatements.org/page/InC/1.0/ | * |
| dc.subject | EAE | en |
| dc.subject | FGF | en |
| dc.subject | FGFR1 | en |
| dc.subject | oligodendrocytes | en |
| dc.subject | MS | en |
| dc.subject.ddc | ddc:570 | de_DE |
| dc.title | Evaluation of the fibroblast growth factor receptor 1 (FGFR1) in experimental autoimmune encephalomyelitis (EAE) | en |
| dc.title.alternative | Bewertung des Fibroblasten-Wachstumsfaktor-Rezeptors FGFR1 bei experimenteller autoimmuner Enzephalomyelitis (EAE) | de_DE |
| dc.type | doctoralThesis | de_DE |
| dcterms.dateAccepted | 2015-02-19 | |
| local.affiliation | FB 08 - Biologie und Chemie | de_DE |
| thesis.level | thesis.doctoral | de_DE |
| local.opus.id | 11358 | |
| local.opus.institute | Institute of Animal Physiology | de_DE |
| local.opus.fachgebiet | Biologie | de_DE |
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