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dc.contributor.authorMamazhakypov, Argen
dc.date.accessioned2023-03-16T20:20:00Z
dc.date.available2020-05-04T10:53:28Z
dc.date.available2023-03-16T20:20:00Z
dc.date.issued2019
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-150877
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/15402
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-14784
dc.description.abstractBackground: Right ventricular (RV) failure determines the survival and outcome of patients with pulmonary hypertension (PH) with different etiologies. Circulating osteopontin (OPN) levels are elevated in patients with PH and correlate with RV dysfunction in those patients. We, therefore, hypothesized that OPN deficient mice are protected from deleterious RV remodeling and the reconstitution of OPN with chronic administration of recombinant OPN (rOPN) in those mice abolish the effects of OPN deficiency on the RV in a mouse model of RV failure. Methods: We performed sham or pulmonary artery banding (PAB) surgery in OPN deficient (OPN KO) and wildtype (WT) mice and treated them with rOPN for 3 weeks. Results: PAB surgery caused a severe increase in RV systolic pressure and RV remodeling and dysfunction in both OPN KO and WT mice as shown by invasive hemodynamic and echocardiographic measurements. rOPN treatment had no effects on the parameters of RV remodeling and dysfunction in both OPN KO and WT mice. Despite similar degrees of RV remodeling, PAB-operated OPN KO mice displayed increased mortality, however, treatment with rOPN improved survival of those mice. Conclusions: Lack of OPN led to the increased mortality of mice with RV failure indicating the crucial role of OPN in this condition. In addition, improved survival of OPN KO mice with rOPN treatment suggests the therapeutic potential of OPN for the treatment of RV failure.en
dc.language.isoende_DE
dc.rightsIn Copyright*
dc.rights.urihttp://rightsstatements.org/page/InC/1.0/*
dc.subjectosteopontinen
dc.subjectright ventricleen
dc.subjectpulmonary artery bandingen
dc.subject.ddcddc:570de_DE
dc.titleRole of Osteopontin in Right Ventricular Remodelingen
dc.typedoctoralThesisde_DE
dcterms.dateAccepted2019-12-10
local.affiliationFB 11 - Medizinde_DE
thesis.levelthesis.doctoralde_DE
local.opus.id15087
local.opus.instituteCardio-Pulmonary Institute (CPI) and Department of Pulmonary Pharmacotherapyde_DE
local.opus.fachgebietMedizinde_DE


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