| dc.contributor.author | Kaiser, Anna | |
| dc.contributor.author | Schaefer, Sylva M. | |
| dc.contributor.author | Behrendt, Inken | |
| dc.contributor.author | Eichner, Gerrit | |
| dc.contributor.author | Fasshauer, Mathias | |
| dc.date.accessioned | 2023-04-13T13:47:30Z | |
| dc.date.available | 2023-04-13T13:47:30Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/16219 | |
| dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-15601 | |
| dc.description.abstract | The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford WebQ). Cox proportional hazard regression models for all-cause mortality were used with sugar intake from different sources included as penalised cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12·3 years, 8576 (4·6 %) deaths occurred. FS but not intrinsic sugars were significantly and dose-dependently associated with hazard ratio (HR) for all-cause mortality. The association with all-cause mortality was significant and dose dependent for FS in beverages, but not in solids with the mean (CI) HR at 50 g/d v. 0 g/d consumption at 1·10, 95 % CI (1·07, 1·14) and 1·01, 95 % CI (0·98, 1·03), respectively. Within the beverages subcategories, a significant dose-dependent association with mortality was detected for FS in soda/fruit drinks and milk-based drinks whereas this relation was NS for FS in pure juice and tea/coffee. FS in four different subtypes of solids, i.e. treats, cereals, toppings and sauces, were not positively associated with all-cause mortality. Major findings were robust in sensitivity analyses. In conclusion, only some FS sources were associated with all-cause mortality. Interventions targeting FS subtypes might be most effective concerning mortality if focused on the reduction of soda/fruit drinks and milk-based sugary drinks; however, the present results need to be confirmed by independent studies. | |
| dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64 | |
| dc.language.iso | en | |
| dc.rights | Namensnennung 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Carbohydrates | |
| dc.subject | Mortality | |
| dc.subject | Prospective cohort study | |
| dc.subject | Sugar | |
| dc.subject | UK Biobank | |
| dc.subject.ddc | ddc:640 | |
| dc.subject.ddc | ddc:360 | |
| dc.title | Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants | |
| dc.type | article | |
| local.affiliation | FB 09 - Agrarwissenschaften, Ökotrophologie und Umweltmanagement | |
| local.project | SFB 1052/2 C6 | |
| local.source.spage | 294 | |
| local.source.epage | 303 | |
| local.source.journaltitle | British journal of nutrition | |
| local.source.volume | 130 | |
| local.source.number | 2 | |
| local.source.uri | https://doi.org/10.1017/S0007114522003233 | |
