Auflistung JLUdocs nach Autor "Dietel, Eric"
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Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling
Brobeil, Alexander; Chehab, Rajaa; Dietel, Eric; Gattenlöhner, Stefan; Wimmer, Monika (2017)Protein protein interactions play a pivotal role in normal cellular functions as well as in carcinogenesis. The protein protein interactions form functional clusters during signal transduction. To elucidate the fine ... -
Crosstalks of the PTPIP51 interactome revealed in Her2 amplified breast cancer cells by the novel small molecule LDC3/Dynarrestin.
Dietel, Eric; Brobeil, Alexander; Delventhal, Lucas; Tag, Claudia; Gattenlöhner, Stefan; Wimmer, Monika (2019)LDC3/Dynarrestin, an aminothiazole derivative, is a recently developed small molecule, which binds protein tyrosine phosphatase interacting protein 51 (PTPIP51). PTPIP51 interacts with various proteins regulating different ... -
Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells
Dietel, Eric; Brobeil, Alexander; Tag, Claudia; Gattenloehner, Stefan; Wimmer, Monika (2018)Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more ... -
The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51
Dietel, Eric; Brobeil, Alexander; Gattenlohner, Stefan; Wimmer, Monika (2018)The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt ... -
PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
Dietel, Eric; Brobeil, Alexander; Tag, Claudia; Gattenlöhner, Stefan; Wimmer, Monika (2020) -
The role of the scaffolding protein PTPIP51 in signal transduction in Her2 amplified breast cancer cells
Dietel, Eric (2020)In summary, protein-protein interactions are the foundation of all signaling events in normal cells as well as in tumor cells. The condensation of the studies displays PTPIP51 as a conductor in the cellular orchestra. We ...