Auflistung JLUdocs nach Autor "Mahavadi, Poornima"
Anzeige der Dokumente 1-10 von 10
-
BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis
Chillappagari, Shashipavan; Guenther, Andreas; Mahavadi, Poornima (2023)Idiopathic pulmonary fibrosis (IPF) is a dreadful and fatal disease of unknown etiology, for which no cure exists. Autophagy, a lysosomal cellular surveillance pathway is insufficiently activated in both alveolar epithelial ... -
Clinical and Functional Characteristics of Patients with Unclassifiable Interstitial Lung Disease (uILD): Long-Term Follow-Up Data from European IPF Registry (eurIPFreg)
Krauss, Ekaterina; El-Guelai, Mustapha; Pons-Kühnemann, Jörn; Dartsch, Ruth; Tello, Silke; Korfei, Martina; Mahavadi, Poornima; Breithecker, Andreas; Fink, Ludger; Stoehr, Mark; Majeed, Raphael W.; Seeger, Werner; Crestani, Bruno; Günther, Andreas (2020) -
Evaluation of Regional Pulmonary Ventilation in Spontaneously Breathing Patients with Idiopathic Pulmonary Fibrosis (IPF) Employing Electrical Impedance Tomography (EIT): A Pilot Study from the European IPF Registry (eurIPFreg)
Krauss, Ekaterina; van der Beck, Daniel; Schmalz, Isabel; Wilhelm, Jochen; Tello, Silke; Dartsch, Ruth; Mahavadi, Poornima; Korfei, Martina; Teschner, Eckhard; Seeger, Werner; Günther, Andreas (2021) -
Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank
Krauss, Ekaterina; Froehler, Maike; Degen, Maria; Mahavadi, Poornima; Dartsch, Ruth C.; Korfei, Martina; Ruppert, Clemens; Seeger, Werner; Guenther, Andreas (2019)Background: New biomarkers are urgently needed to facilitate diagnosis in Interstitial Lung Diseases (ILD), thus reducing the need for invasive procedures, and to enable tailoring and monitoring of medical treatment.Methods: ... -
PACS2–TRPV1 axis is required for ER–mitochondrial tethering during ER stress and lung fibrosis
Knoell, Jessica; Chillappagari, Shashi; Knudsen, Lars; Korfei, Martina; Dartsch, Ruth; Jonigk, Danny; Kuehnel, Mark P.; Hoetzenecker, Konrad; Guenther, Andreas; Mahavadi, Poornima (2022) -
Die porcine organotypische Netzhautkultur: Optimierung der Kulturdauer und Anwendung in der gentherapeutischen Forschung
Weller, Maria (2022)Erbliche Retinadystrophien sind eine sehr heterogene Gruppe an Erkrankungen mit insgesamt über zwei Millionen Betroffenen und können bisher nicht geheilt werden. Durch die große Heterogenität und die sehr vielen betroffenen ... -
Role of impaired lysosomal trafficking in the development of lung fibrosis in a murine model of Hermansky-Pudlak syndrome
Mahavadi, Poornima (2009)Hermansky-Pudlak syndrome (HPS) comprises of a group of rare hereditary disorders primarily affecting transport within lysosome related organelles. Up to now, 16 (mice) and 8 (human) genes, respectively, ... -
Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option
Korfei, Martina; Mahavadi, Poornima; Guenther, Andreas (2022) -
Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis
Chillappagari, Shashipavan; Schwarz, Julian; Kesireddy, Vidyasagar; Knoell, Jessica; Korfei, Martina; Hoetzenecker, Konrad; Schmitz, M. Lienhard; Behl, Christian; Bellusci, Saverio; Guenther, Andreas; Mahavadi, Poornima (2022) -
Understanding the crucial impact of deregulated autophagy & lysosomal stress in diffuse parenchymal lung diseases
Mahavadi, Poornima (2021)The data provided in this work strongly support the concept that alterations in the autophagy-lysosomal system contribute to alveolar epithelial cell injury and apoptosis, representing a key trigger in the development of ...