Browsing JLUdocs by Author "Roeb, Elke"
Now showing items 1-20 of 39
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A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape
Lehmann, Felix; Slanina, Heiko; Roderfeld, Martin; Roeb, Elke; Trebicka, Jonel; Ziebuhr, John; Gerlich, Wolfram H.; Schüttler, Christian G.; Schlevogt, Bernhard; Glebe, Dieter (2023)Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity, and transmissibility. A patient positive for HBV DNA and detectable ... -
Aktivierung des Protoonkogens c-Jun durch Schistosoma mansoni-Ei-Antigene
Wolters, Friederike Caroline Christine (2022)Schistosomiasis ist eine parasitäre Infektionserkrankung und wird zu den vernachlässigten Tropenkrankheiten (engl. neglected tropical diseases) gezählt. Weltweit erhielten im Jahr 2019 ca. 236 Mio. Menschen eine prophylaktische ... -
Analyse der Infektiosität des Hepatitis-B-Virus des Wollaffen in vitro
Steinbeck, Paul (2022)Das Ziel der Arbeit war die Analyse des zoonotischen Potentials von Woolly Monkey Hepatitis B Viren (WMHBV) über Infektionsversuche in HepG2-Zellen, die das Natrium/Taurocholat Kotransporter Polypeptid (NTCP) verschiedener ... -
Assessment of pathologic increase in liver stiffness enables earlier diagnosis of CFLD: Results from a prospective longitudinal cohort study
Klotter, Victoria; Gunchick, Caroline; Siemers, Enno; Rath, Timo; Hudel, Helge; Naehrlich, Lutz; Roderfeld, Martin; Roeb, Elke (2017)About 30% of patients with Cystic Fibrosis (CF) develop CF-associated liver disease (CFLD). Recent studies have shown that transient elastography (TE), as a method to quantify liver stiffness, allows non-invasive diagnosis ... -
C1q/TNF-Related Protein 3 (CTRP-3) Deficiency of Adipocytes Affects White Adipose Tissue Mass but Not Systemic CTRP-3 Concentrations
Schmid, Andreas; Roderfeld, Martin; Gehl, Jonas; Roeb, Elke; Nist, Andrea; Chung, Ho-Ryun; Stiewe, Thorsten; Karrasch, Thomas; Schäffler, Andreas (2021) -
Caspase-Cleaved Keratin 18 Measurements Identified Ongoing Liver Injury after Bariatric Surgery
Hempel, Felix; Roderfeld, Martin; Müntnich, Lucas John; Albrecht, Jens; Oruc, Ziya; Arneth, Borros; Karrasch, Thomas; Pons-Kühnemann, Jörn; Padberg, Winfried; Renz, Harald; Schäffler, Andreas; Roeb, Elke (2021) -
Changes in the lipid profile of hamster liver after Schistosoma mansoni infection, characterized by mass spectrometry imaging and LC–MS/MS analysis
Wiedemann, Katja R.; Peter Ventura, Alejandra; Gerbig, Stefanie; Roderfeld, Martin; Quack, Thomas; Grevelding, Christoph G.; Roeb, Elke; Spengler, Bernhard (2022) -
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice
Irungbam, Karuna; Roderfeld, Martin; Glimm, Hannah; Hempel, Felix; Schneider, Franziska; Hehr, Laura; Glebe, Dieter; Churin, Yuri; Morlock, Gertrud; Yüce, Imanuel; Roeb, Elke (2020) -
Circulating Adipokines and Hepatokines Serve as Diagnostic Markers during Obesity Therapy
Schmid, Andreas; Arians, Miriam; Burg-Roderfeld, Monika; Karrasch, Thomas; Schäffler, Andreas; Roderfeld, Martin; Roeb, Elke (2022) -
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice
Hempel, Felix; Roderfeld, Martin; Savai, Rajkumar; Sydykov, Akylbek; Irungbam, Karuna; Schermuly, Ralph; Voswinckel, Robert; Köhler, Kernt; Churin, Yury; Kiss, Ladislau; Bier, Jens; Pons-Kühnemann, Jörn; Roeb, Elke (2019) -
Diagnostic and Therapy of Nonalcoholic Fatty Liver Disease: A Narrative Review
Roeb, Elke (2021) -
Does Schistosoma Mansoni Facilitate Carcinogenesis?
Bülow, Verena von; Lichtenberger, Jakob; Grevelding, Christoph; Falcone, Franco Harald; Roeb, Elke; Roderfeld, Martin (2021) -
Fibrozyten: Fibrogene Zellen des Knochenmarks und ihr Beitrag im Mausmodell der Thioacetamid-induzierten Leberfibrose
Hempel, Felix (2023)Leberfibrose ist gekennzeichnet durch die pathologische Expansion extrazellulärer Matrix infolge dysregulierter Wundheilungsprozesse. Sie stellt einen gemeinsamen Mechanismus zahlreicher chronischer Lebererkrankungen dar ... -
Fructose and Non-Alcoholic Steatohepatitis
Roeb, Elke; Weiskirchen, Ralf (2021) -
Gastroenterologie in Gießen
Roeb, Elke (2006) -
Genomic methylation inhibits expression of Hepatitis B virus envelope protein in transgenic mice : a non-infectious mouse model to dtudy silencing of HBV surface antigen genes
Graumann, Franziska; Churin, Yuri; Tschuschner, Annette; Reifenberg, Kurt; Glebe, Dieter; Roderfeld, Martin; Roeb, Elke (2015)Objective:The Hepatitis B virus genome persists in the nucleus of virus infected hepatocytes where it serves as template for viral mRNA synthesis. Epigenetic modifications, including methylation of the CpG islands contribute ... -
Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice
Zahner, Daniel; Glimm, Hannah; Matono, Tomomitsu; Churin, Yuri; Herebian, Diran; Mayatepek, Ertan; Köhler, Kernt; Gattenlöhner, Stefan; Stinn, Anne; Tschuschner, Annette; Roderfeld, Martin; Roeb, Elke (2017)Understanding of the pathophysiology of cholestasis associated carcinogenesis could challenge the development of new personalized therapeutic approaches and thus improve prognosis. Simultaneous damage might aggravate hepatic ... -
Hepatitis C Virus Downregulates Core Subunits of Oxidative Phosphorylation, Reminiscent of the Warburg Effect in Cancer Cells
Gerresheim, Gesche; Roeb, Elke; Michel, Audrey; Niepmann, Michael (2019) -
Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice
Härle, Lukas; von Bülow, Verena; Knedla, Lukas; Stettler, Frederik; Müller, Heike; Zahner, Daniel; Haeberlein, Simone; Windhorst, Anita; Tschuschner, Annette; Burg-Roderfeld, Monika; Köhler, Kernt; Grevelding, Christoph G.; Roeb, Elke; Roderfeld, Martin (2023)Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival ...