Show simple item record

dc.contributor.advisorAcker, Till
dc.contributor.advisorStein, Marco
dc.contributor.authorNguyen, Phuong
dc.date.accessioned2022-05-02T12:32:13Z
dc.date.available2022-05-02T12:32:13Z
dc.date.issued2021
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/757
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-666
dc.description.abstractGlioblastoma multiforme (GBM) is one of the most lethal tumors known to man. This lethality is partly attributable to its rapid growth, which creates intratumoral regions scarce of oxygen and nutrients. GBM adapts to oxygen scarcity by activating the hypoxic response via hypoxia-inducible factor (HIF), thereby ensuring their survival and progression. HIF, in turn, is tightly regulated by prolyl hydroxylase domain-containing proteins. This work aims to characterize metabolic factors that influence the function of prolyl hydroxylase domain-containing proteins in GBM, including the metabolites glutamine, glutamate and alpha-ketoglutarate, and the citric acid cycle enzyme isocitrate dehydrogenase.de_DE
dc.language.isoende_DE
dc.rightsIn Copyright*
dc.rights.urihttp://rightsstatements.org/page/InC/1.0/*
dc.subjectglioblastomade_DE
dc.subjecthypoxiade_DE
dc.subjecttumor microenvironmentde_DE
dc.subjecttumor metabolismde_DE
dc.subject.ddcddc:610de_DE
dc.titleMetabolic regulation of prolyl hydroxylase domain-containing protein and hypoxia-inducible factor in glioblastoma cells in-vitrode_DE
dc.typedoctoralThesisde_DE
dcterms.dateAccepted2022-02-01
local.affiliationFB 11 - Medizinde_DE
thesis.levelthesis.doctoralde_DE


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright