Belapurkar, RatnalRatnalBelapurkarPfisterer, MaximilianMaximilianPfistererDreute, JanJanDreuteWerner, SebastianSebastianWernerZukunft, SvenSvenZukunftFleming, IngridIngridFlemingKracht, MichaelMichaelKrachtSCHMITZ, M. LienhardM. LienhardSCHMITZ2024-10-022024-10-022023https://jlupub.ub.uni-giessen.de/handle/jlupub/19550https://doi.org/10.22029/jlupub-18908The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show that HIF-1α protein levels transiently increase during the G1 phase of the cell cycle (designated as G1-HIF) in an AMP-activated protein kinase (AMPK)-dependent manner. The transient elimination of G1-HIF by a degron system revealed its contribution to cell survival under unfavorable metabolic conditions. Indeed, G1-HIF plays a key role in the cell cycle-dependent expression of genes encoding metabolic regulators and the maintenance of mTOR activity under conditions of nutrient deprivation. Accordingly, transient elimination of G1-HIF led to a significant reduction in the concentration of key proteinogenic amino acids and carbohydrates. These data indicate that G1-HIF acts as a cell cycle-dependent surveillance factor that prevents the onset of starvation-induced apoptosis.enNamensnennung 4.0 Internationalddc:610