Pardun, KarolineKarolinePardunTreccani, LauraLauraTreccaniVolkmann, EikeEikeVolkmannStreckbein, PhilippPhilippStreckbeinHeiss, ChristianChristianHeissGerlach, Juergen W.Juergen W.GerlachMaendl, StephanStephanMaendlRezwan, KuroschKuroschRezwan2023-06-022017-01-252023-06-022015http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-124574https://jlupub.ub.uni-giessen.de/handle/jlupub/16362http://dx.doi.org/10.22029/jlupub-15742An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg2+ ions. The magnesiumcontaining coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.enIn Copyrightzirconiacalcium phosphatemagnesiumbioactivityimplant coatingddc:610