Dreute, JanJanDreutePfisterer, MaximilianMaximilianPfistererSchmitz, M. LienhardM. LienhardSchmitz2025-03-192025-03-192024https://jlupub.ub.uni-giessen.de/handle/jlupub/20334https://doi.org/10.22029/jlupub-19685The family of hypoxia-inducible transcription factors (HIF) is typically activated by low oxygen concentrations. We observed a transient increase of the HIF-1α protein levels during the G1 phase of the cell cycle, designated as G1-HIF. This cell cycle-regulated form of HIF ensures cell proliferation and survival under conditions of metabolic stress by increasing the levels of key metabolites during the cell cycle. The generation of G1-HIF depends on an AMPK-mediated signaling pathway.enNamensnennung 4.0 Internationalddc:610