Heinze, Roger J.Roger J.HeinzeSekerina, SvetlanaSvetlanaSekerinaWinkler, InesInesWinklerBiertuempfel, ChristianChristianBiertuempfelOretskaya, Tatiana S.Tatiana S.OretskayaKubareva, ElenaElenaKubarevaFriedhoff, PeterPeterFriedhoff2023-06-022013-07-112023-06-022012http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-98851https://jlupub.ub.uni-giessen.de/handle/jlupub/16399http://dx.doi.org/10.22029/jlupub-15779The DNA repair protein MutS forms clamp-like structures on DNA that search for and recognize base mismatches leading to ATP-transformed signaling clamps. In this study, the mobile MutS clamps were trapped on DNA in a functional state using single-cysteine variants of MutS and thiol-modified homoduplex or heteroduplex DNA. This approach allows stabilization of various transient MutS-DNA complexes and will enable their structural and functional analysis.enIn Copyrightddc:570