Wernicke, Anna-KatharinaAnna-KatharinaWernickeChurin, YuriYuriChurinSheridan, DianaDianaSheridanWindhorst, AnitaAnitaWindhorstTschuschner, AnnetteAnnetteTschuschnerGattenlöhner, StefanStefanGattenlöhnerRoderfeld, MartinMartinRoderfeldRoeb, ElkeElkeRoeb2022-11-182017-07-132022-11-182016http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-129827https://jlupub.ub.uni-giessen.de/handle/jlupub/9331http://dx.doi.org/10.22029/jlupub-8719An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout. The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions.enNamensnennung 3.0 InternationalMMPneoplasiacolon canceradenomaimmunoreactive scoringddc:610