Schild, MariusMariusSchildEichner, GerritGerritEichnerBeiter, ThomasThomasBeiterZügel, MartinaMartinaZügelKrumholz-Wagner, IlkeIlkeKrumholz-WagnerHudemann, JensJensHudemannPilat, ChristianChristianPilatKrüger, KarstenKarstenKrügerNiess, Andreas M.Andreas M.NiessSteinacker, Jürgen M.Jürgen M.SteinackerMooren, Frank C.Frank C.Mooren2022-11-182016-10-282022-11-182016http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-123161https://jlupub.ub.uni-giessen.de/handle/jlupub/9220http://dx.doi.org/10.22029/jlupub-8608Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.enNamensnennung 3.0 Internationalddc:610