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Item Die Bedeutung der Gentechnik für die Diagnose und Prävention der Hepatitis B Virus Infektionen(1978) Gerlich, Wolfram H.Item Berufstätigkeit von HBs-Antigen positiven Chirurgen(1978) Gerlich, Wolfram H.Item Bestimmungsmethoden der Hepatitis B-Antigene und ihrer Antikörper(1976) Gerlich, Wolfram H.Item Comparison of in vitro and in vivo dissolution for the study of colonic drug absorption(1993) Brockmeier, DierkItem Conference on chronically-evolving viral hepatitis - Congress report(1993) Gerlich, Wolfram H.Item Cystic fibrosis transmembrane conductance regulator biomarkers in `real life´ : can we evaluate individual efficacy of cystic fibrosis transmembrane conductance regulator therapy?(2015) Koningsbruggen-Rietschel, Silke van; Nährlich, LutzItem Enhanced osteogenesis on titanium implants by UVB photofunctionalization of hydrothermally grown TiO2 coatings(2015) Lorenzetti, Martina; Dakischew, Olga; Trinkaus, Katja; Lips, Katrin Susanne; Schnettler, Reinhard; Kobe, Spomenka; Novak, SasaEven though Ti-based implants are the most used materials for hard tissue replacement, they may present lack of osseointegration on the long term, due to their inertness. Hydrothermal treatment (HT) is a useful technique for the synthesis of firmly attached, highly crystalline coatings made of anatase titanium dioxide (TiO2), providing favorable nanoroughness and higher exposed surface area, as well as greater hydrophilicity, compared to the native amorphous oxide on pristine titanium. The hydrophilicity drops even more by photofunctionalization of the nanostructured TiO2-anatase coatings under UV light. Human mesenchymal stem cells exhibited a good response to the combination of the positive surface characteristics, especially in respect to the UVB pre-irradiation. The results showed that the cells were not harmed in terms of viability; even more, they were encouraged to differentiate in osteoblasts and to become osteogenically active, as confirmed by the calcium ion uptake and the formation of well-mineralized, bone-like nodule structures. In addition, the enrichment of hydroxyl groups on the HT-surfaces by UVB photofunctionalization accelerated the cell differentiation process and greatly improved the osteogenesis in comparison with the nonirradiated samples. The optimal surface characteristics of the HT-anatase coatings as well as the high potentiality of the photo-induced hydrophilicity, which was reached during a relatively short pre-irradiation time (5 h) with UVB light, can be correlated with better osseointegration ability in vivo; among the samples, the superior biological behavior of the roughest and most hydrophilic HT coating makes it a good candidate for further studies and applications.Item Hepatitis B surface proteins(1991) Gerlich, Wolfram H.Item Heritability of strabismus : Genetic influence is specific to eso-deviation and independent of refractive error(2012) Sanfilippo, Paul G.; Hammond, Christopher J.; Staffieri, Sandra E.; Kearns, Lisa S.; Melissa Liew, S. H.; Barbour, Julie M.; Hewitt, Alex W.; Ge, Dongliang; Snieder, Harold; MacKinnon, Jane R.; Brown, Shayne A.; Lorenz, Birgit; Spector, Tim D.; Martin, Nicholas G.; Wilmer, Jeremy B.; Mackey, David A.Strabismus represents a complex oculomotor disorder characterized by the deviation of one or both eyes and poor vision. A more sophisticated understanding of the genetic liability of strabismus is required to guide searches for associated molecular variants. In this classical twin study of 1,462 twin pairs, we examined the relative influence of genes and environment in comitant strabismus, and the degree to which these influences can be explained by factors in common with refractive error. Participants were examined for the presence of latent ( phoria ) and manifest ( tropia ) strabismus using cover uncover and alternate cover tests. Two phenotypes were distinguished: eso-deviation (esophoria and esotropia) and exo-deviation (exophoria and exotropia). Structural equation modeling was subsequently employed to partition the observed phenotypic variation in the twin data into specific variance components. The prevalence of eso-deviation and exo-deviation was 8.6% and 20.7%, respectively. For eso-deviation, the polychoric correlation was significantly greater in monozygotic (MZ) (r = 0.65) compared to dizygotic (DZ) twin pairs (r = 0.33), suggesting a genetic role (p = .003). There was no significant difference in polychoric correlation between MZ (r = 0.55) and DZ twin pairs (r = 0.53) for exo-deviation (p = .86), implying that genetic factors do not play a significant role in the etiology of exo-deviation. The heritability of an eso-deviation was 0.64 (95% CI 0.50 0.75). The additive genetic correlation for eso-deviation and refractive error was 0.13 and the bivariate heritability (i.e., shared variance) was less than 1%, suggesting negligible shared genetic effect. This study documents a substantial heritability of 64% for eso-deviation, yet no corresponding heritability for exo-deviation, suggesting that the genetic contribution to strabismus may be specific to eso-deviation. Future studies are now needed to identify the genes associated with eso-deviation and unravel their mechanisms of action.Item High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease(2015) Liebetrau, Christoph; Gaede, Luise; Dörr, Oliver; Hoffmann, Jedrzej; Wolter, Jan S.; Weber, Michael; Rolf, Andreas; Hamm, Christian W.; Nef, Holger M.; Möllmann, HelgeBackground: The average diagnostic sensitivity of exercise stress tests (ESTs) is lower than that of other non-invasive cardiac stress tests. The aim of the study was to examine whether high-sensitivity cardiac troponin T (hs-cTnT) or copeptin concentrations rise in response to inducible myocardial ischaemia and may improve the diagnostic accuracy of ESTs.Methods and results: An EST was performed stepwise on a bicycle ergometer by 383 consecutive patients with suspected or progression of coronary artery disease (CAD). In addition venous blood samples for measurement of hs-cTnT and copeptin were collected prior to EST, at peak exercise, and 4 h after EST. Coronary angiography was assessed for all patients. Patients with significant CAD (n=224) were more likely to be male and older compared to patients with non-significant CAD (n=169). Positive EST was documented in 125 (55.8%) patients with significant CAD and in 69 (43.4%) patients with non-significant CAD. Copeptin and hs-cTnT concentrations at baseline were higher in patients with significant CAD (copeptin: 10.8 pmol/l (interquartile range (IQR) 8.1 15.6) vs 9.4 pmol/l (IQR 7.1 13.9); p=0.04; hs-cTnT: 3.0 ng/l (IQR <3.0 5.4) vs <3.0 ng/l (IQR <3.0); p=0.006). Hs-cTnT improved sensitivity (61.6% vs 55.8%), specificity (67.7% vs 56.6%) and the positive predictive value (PPV) (72.3% vs 64.4%) and negative (55.2% vs 47.6%) predictive value (NPV) of EST. Copeptin could not improve sensitivity (55.4% vs 55.8%) and reduced specificity, PPV and NPV.Conclusions: The measurement of hs-cTnT during EST improves sensitivity, specificity, and positive and negative predictive values. In contrast, measurement of copeptin does not improve diagnostic sensitivity and reduces specificity.Item In vitro in vivo correlation, a time scaling problem? : Evaluation of mean times(1984) Brockmeier, DierkItem In vitro-in vivo correlation of dissolution using moments of dissolution and transit times(1986) Brockmeier, DierkItem Intracoronary bone marrow cell application for terminal heart failure in children(2012) Rupp, Stefan; Jux, Christian; Bönig, Halvard; Bauer, Jürgen; Tonn, Torsten; Seifried, Erhard; Dimmeler, Stefanie; Zeiher, Andreas M.; Schranz, DietmarIntroduction In spite of tremendous progress in the medical and surgical treatment of children with congenital heart disease and dilated cardiomyopathy achieved during the past few decades, for some children a heart transplant remains the only option. Clinically relevant benefits of intracoronary injection of autologous stem cells on cardiac function and remodelling have been demonstrated in adult patients with acute myocardial infarction. Experience with autologous stem cell therapy in children with severe congenital or acquired pump failure is limited to a small number of case reports. Method and results Between 2006 and 2010, nine severely ill children were treated with intracoronary infusion of autologous bone marrow-derived mononuclear cells as part of a compassionate therapy in our centre. No procedure-related unexpected adverse events occurred. There was one patient on extracorporeal membrane oxygenation who died of haemorrhage unrelated to the procedure; three patients proceeded to heart transplantation once a donor heart became available. The other five patients showed an improvement with respect to New York Heart Association classification (greater than or equal to 1), brain natriuretic peptide serum levels, and ejection fraction. Conclusion Similar to adults, intracoronary injection of autologous bone marrow cell is technically feasible and safe for children. On the basis of our data, we propose to perform a pilot study for children with congestive heart failure, to formally assess the efficacy of intracoronary autologous bone marrow cell therapy.Item Laboratoriumsdiagnostik der Hepatitis B-Virus-Infektion(1978) Gerlich, Wolfram H.Item Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior(2015) Pardun, Karoline; Treccani, Laura; Volkmann, Eike; Streckbein, Philipp; Heiss, Christian; Gerlach, Juergen W.; Maendl, Stephan; Rezwan, KuroschAn important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg2+ ions. The magnesiumcontaining coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.Item Magnetic resonance imaging of an aortopulmonary window type three, with aortic atresia and interrupted aortic arch type B(2012) Vogel, Melanie; Schranz, Dietmar; Bauer, JuergenItem Model-free evaluation and mean-time concept in pharmacokinetics(1986) Brockmeier, DierkItem Myocardial biopsies differentiate between myocyte- andendothelial-targeted myocarditis : letter to the editor(2012) Schranz, Dietmar; Michel-Behnke, InaItem Natur und Nachweis der Hepatitis-Viren(1976) Gerlich, Wolfram H.