Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS
dc.contributor.author | Arneth, Borros | |
dc.date.accessioned | 2022-11-18T09:51:10Z | |
dc.date.available | 2016-07-20T10:53:38Z | |
dc.date.available | 2022-11-18T09:51:10Z | |
dc.date.issued | 2015 | |
dc.description.abstract | BACKGROUND: Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples were analyzed for activation capacity and the activatability of CD4+ and CD8+ T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP 68-82 fragment. METHODS: Whole blood samples from healthy human subjects were compared with samples from patients with multiple sclerosis (MS). In particular, the expression of CD69, a surface marker of T-lymphocyte activity, was measured via flow cytometry before and after 14h of incubation with human total MBP, MBP 104-118 fragment and/or guinea pig MBP 68-82 fragment. The results were compared between 15 patients with MS and 15 healthy subjects. RESULTS: In response to all three MBP forms, CD4+ and CD8+ T-lymphocytes from patients with MS demonstrated greater activatability than those from healthy subjects. These results indicate that in patients with MS, latent pre-activation to MBP epitopes results in an increased activation capacity of T-lymphocytes. CONCLUSION: This effect may occur because immunization against MBP (at least in a subset of patients) plays a pathophysiological role in MS pathogenesis. Alternatively, this result may represent a non-specific, bystander autoimmune phenomenon. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-121894 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9197 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8585 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung 3.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 12189 | |
local.opus.institute | Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics | de_DE |
local.source.freetext | Journal of Translational Medicine 13:341 | de_DE |
local.source.uri | https://doi.org/10.1186/s12967-015-0715-6 |
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