Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
dc.contributor.author | Knörr, Fabian | |
dc.contributor.author | Damm-Welk, Christine | |
dc.contributor.author | Ruf, Stephanie | |
dc.contributor.author | Singh, Vijay Kumar | |
dc.contributor.author | Zimmermann, Martin | |
dc.contributor.author | Reiter, Alfred | |
dc.contributor.author | Woessmann, Wilhelm | |
dc.date.accessioned | 2022-11-18T09:53:47Z | |
dc.date.available | 2019-05-20T13:53:39Z | |
dc.date.available | 2022-11-18T09:53:47Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-gamma, interferon gamma-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients immune response. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-146270 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9462 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8850 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung - Nicht-kommerziell 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 14627 | |
local.opus.institute | NHL-BFM Study Center, Department of Pediatric Hematology and Oncology | de_DE |
local.source.freetext | Haematologica 103(3):477-485 | de_DE |
local.source.uri | https://doi.org/10.3324/haematol.2017.177972 |
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