Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice
dc.contributor.author | Reutzel, Martina | |
dc.contributor.author | Grewal, Rekha | |
dc.contributor.author | Silaidos, Carmina | |
dc.contributor.author | Zotzel, Jens | |
dc.contributor.author | Marx, Stefan | |
dc.contributor.author | Tretzel, Joachim | |
dc.contributor.author | Eckert, Gunter P. | |
dc.date.accessioned | 2022-11-18T09:54:34Z | |
dc.date.available | 2020-06-03T08:49:12Z | |
dc.date.available | 2022-11-18T09:54:34Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Aging represents a major risk factor for developing neurodegenerative diseases such as Alzheimer´s disease (AD). As components of the Mediterranean diet, olive polyphenols may play a crucial role in the prevention of AD. Since mitochondrial dysfunction acts as a final pathway in both brain aging and AD, respectively, the effects of a mixture of highly purified olive secoiridoids were tested on cognition and ATP levels in a commonly used mouse model for brain aging. Over 6 months, female NMRI mice (12 months of age) were fed with a blend containing highly purified olive secoiridoids (POS) including oleuropein, hydroxytyrosol and oleurosid standardized for 50 mg oleuropein/kg diet (equivalent to 13.75 mg POS/kg b.w.) or the study diet without POS as control. Mice aged 3 months served as young controls. Behavioral tests showed deficits in cognition in aged mice. Levels of ATP and mRNA levels of NADH-reductase, cytochrome-c-oxidase, and citrate synthase were significantly reduced in the brains of aged mice indicating mitochondrial dysfunction. Moreover, gene expression of Sirt1, CREB, Gap43, and GPx-1 was significantly reduced in the brain tissue of aged mice. POS-fed mice showed improved spatial working memory. Furthermore, POS restored brain ATP levels in aged mice which were significantly increased. Our results show that a diet rich in purified olive polyphenols has positive long-term effects on cognition and energy metabolism in the brain of aged mice. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-151857 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9517 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8905 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice | en |
dc.type | article | de_DE |
local.affiliation | FB 09 - Agrarwissenschaften, Ökotrophologie und Umweltmanagement | de_DE |
local.opus.fachgebiet | Haushalts- und Ernährungswissenschaften - Ökotrophologie | de_DE |
local.opus.id | 15185 | |
local.opus.institute | Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy | de_DE |
local.source.freetext | Oxidative Medicine and Cellular Longevity 2018, Article ID 4070935, | de_DE |
local.source.uri | https://doi.org/10.1155/2018/4070935 |
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