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Neue Veröffentlichungen:

Traumatic Knee Joint Dislocation in a Total Knee Arthroplasty with Rupture of the Popliteal Artery and a Subsequent Prosthesis Change: A Case Report
(2025) Tüngler, Tim Ludwig; Pawelke, Jonas; El Khassawna, Thaqif; Heiss, Christian; Knapp, Gero
Introduction: Dislocations of the knee joint due to low-energy trauma following knee arthroplasty are very rare cases. However, when vascular involvement is present, it must be taken very seriously. This study aims to examine the clinical course, diagnostic approach, and surgical management of knee joint dislocation with vascular injury following low-energy trauma in a patient with a pre-existing knee arthroplasty. Case Report: This case report details the instance of a 67-year-old female patient experiencing an anterior dislocation of the knee joint subsequent to a low-energy fall, occurring years after the surgical implantation of a knee joint prosthesis. Clinically and radiologically, an anterior dislocation of the knee joint accompanied by a rupture of the popliteal artery (PI/III segment) was confirmed. The involvement of the popliteal artery was evident in duplex sonography and computed tomography angiography conducted after closed reduction. The surgical intervention involved performing an end-to-end anastomosis of the popliteal artery, followed by the installation of a cemented rotating hinge knee endoprosthesis. Conclusion: Severe knee joint dislocations often require immediate closed reduction and duplex sonography, potentially leading to emergency surgical intervention. Prioritizing vascular and neurological repair before orthopedic treatment is essential, with follow-up assessments for joint stability recommended.
Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance
(2024) Debnath, Ranjan; Elyamany, Osama; Iffland, Jona Ruben; Rauh, Jonas; Siebert, Michael; Andraes, Elisa; Leicht, Gregor; Mulert, Christoph
Introduction: Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance in working memory (WM) tasks. Method: In two sessions, 28 healthy participants received 5 Hz tACS or sham stimulation over the left dorsolateral prefrontal cortex (DLPFC) while performing tasks with high and low WM loads. Resting-state EEG was recorded before and after stimulations for 5 minutes. EEG power was measured at electrodes surrounding the stimulation site. Results: The results showed that tACS significantly improved reaction time (RT) compared to sham stimulation. This effect was task-specific, as tACS improved RT for hit responses only in high WM load trials, with no impact on low-load trials. Moreover, tACS significantly increased EEG power at 5 Hz and in the theta band compared to pre-stimulation levels. Discussion: These findings demonstrate that tACS applied over left DLPFC modulates post-stimulation brain oscillations at the stimulation sites – known as tACS after-effects. Furthermore, the results suggest that 5 Hz tACS enhances response speed by elevating task-related activity in the prefrontal cortex to an optimal level for task performance. Conclusion: In summary, the findings highlight the potential of tACS as a technique for modulating specific brain oscillations, with implications for research and therapeutic interventions.
Females in higher education and leadership: insights from a multi-method approach
(2024) Correa, Alicia; Glas, Maria Gracia; Opara, Jana
Despite constituting more than half of higher education students globally, females remain underrepresented in academic roles, particularly in leadership positions that shape the future direction of higher education and impact society at large. This study, aligned with the UN’s Sustainable Development Goals 4 and 5, examines the gender gap in higher education and leadership across regional, national, and institutional contexts. Through descriptive analyses, surveys, and interviews, the research assesses female representation at various academic levels and identifies key factors influencing career progression. The findings reveal that gender parity in enrolment has been achieved, with Latin America & Caribbean leading, followed by Europe and Central Asia. However, parity in academic roles, such as teaching positions, remains unmet, with Central Asia showing higher female representation than Europe and Latin America & Caribbean. Parity in these roles is projected to be achieved well beyond 2030. Variations within regions, such as internal differences in Central Asia, emphasize the need for more granular analysis. Gender parity in senior and leadership roles is even further from being realized. Perceptions of obstacles faced by women in academia—such as work-life balance challenges and a lack of role models—are consistent across diverse regions and cultures. To address these issues, the results suggest improving visibility, offering mentoring programs, and promoting diverse leadership. Conducted across both developed and developing countries, the study concludes that achieving gender parity in leadership positions remains a distant goal, underscoring the need to reassess strategies to better align with the 2030 Agenda.
Iron regulatory protein 1-deficient mice exhibit hypospermatogenesis
(2025) Harrer, Aileen; Ghatpande, Niraj; Grimaldini, Tiziana; Fietz, Daniela; Kumar, Vishnu; Pleuger, Christiane; Fijak, Monika; Föppl, Dankward T.; Rynio, Lennart P.; Schuppe, Hans-Christian; Pilatz, Adrian; Bartkuhn, Marek; Procida-Kowalski, Tara; Guttmann-Raviv, Noga; Bhushan, Sudhanshu; Meyron-Holtz, Esther G.; Meinhardt, Andreas
Imbalances in testicular iron levels are linked to compromised sperm production and male infertility. Iron regulatory proteins (IRP) 1 and 2 play crucial roles in cellular iron regulation. We investigated the role of IRP1 on spermatogenesis using Irp1-deficient mice (Irp1−/−). Histological analysis of the testis of Irp1−/− mice revealed hypospermatogenesis with a significant reduction in the number of elongated spermatids and daily sperm production compared to wild-type (WT) mice. Flow cytometry of germ cells from WT and Irp1−/− mice showed reduction in spermatocytes and round and elongated spermatids in Irp1−/− mice, which was confirmed by histological and immunofluorescence quantification. Finally, stage VIII of spermatogenesis, crucial for spermatid maturation, was less frequent in Irp1−/− testicular cross-sections. Hypospermatogenesis worsened with age despite unchanged intratesticular iron levels. Mechanistically, this was due to increased oxidative stress indicated by elevated 8-Oxoguanine (8-OxoG) levels, a DNA lesion resulting from reactive oxygen species (ROS). Furthermore, bulk RNA-seq data indicated compromised DNA damage repair and cell cycle processes, including mitosis and meiosis in Irp1−/− mice, which may explain hypospermatogenesis. Our results suggest that IRP1 deletion leads to hypospermatogenesis due to impaired cell cycle progression, decreased DNA damage repair capacity, and oxidative damage. Altogether, this study uncovers a role for IRP1, independent of traditional mechanisms of iron regulation.
Crypt4GH-JS: securely storing sensitive data online with client-side encryption
(2025) Thelen, Fabienne; Hochmuth, Jannis; Griep, Sven; Schwab, Benedikt; Goesmann, Alexander; Förster, Frank
Motivation and Results: Crypt4GH-JS is a browser-ready implementation of the Crypt4GH file encryption standard written in JavaScript. While having minimal to no impact on data upload and download throughput this library enables on-the-fly encryption of arbitrary data in web applications, regardless of whether on the client or server side. As development moves more and more toward cloud-native applications, this library represents a significant step forward for flexible data security in the context of opaque cloud storage systems. Availability and implementation: Crypt4GH-JS can be installed via Node Package Manager (https://www.npmjs.com/package/crypt4gh_js) or through its public GitHub Repository (https://github.com/fathelen/crypt4ghJS), where the source code is available. Crypt4GH-JS can be tested in the browser using our demonstration website, which can be found at: https://fathelen.github.io/crypt4ghJS/.