Willkommen bei JLUpub
JLUpub ist das institutionelle Repositorium der Justus-Liebig-Universität.
JLUpub bietet Mitgliedern und Angehörigen der Universität die Möglichkeit neben wissenschaftlichen Dokumenten auch Forschungsdaten elektronisch zu veröffentlichen und dauerhaft zugänglich zu machen. Alle Veröffentlichungen erhalten einen Digital Object Identifier (DOI) und werden über nationale und internationale Bibliothekskataloge sowie Suchmaschinen nachgewiesen und auffindbar.
Neue Veröffentlichungen:
Item type: Item , Arterial thromboembolism in a cat with transient myocardial thickening(2024) Vollmar, C.; Mitropoulou, A.; Hassdenteufel, E.; Hildebrandt, N.; Schneider, M.Feline arterial thromboembolism has been reported to be secondary to various feline cardiomyopathies; however, it has not been described in cats with transient myocardial thickening. A previously healthy, one-year-old, castrated male cat presented with acute paraparesis and congestive heart failure. Echocardiography revealed asymmetric left ventricular free wall thickening and left atrial enlargement. Antithrombotic treatment and cardiac medication resulted in reperfusion and mobility on day seven in one limb and on day 10 in the other. Different complications were managed successfully, including worsening acute kidney injury, inflammation, pleural effusion, and anemia. After three weeks, the cat was discharged and prescribed oral antithrombotic drugs (clopidogrel and rivaroxaban) and cardiac medication. Within five months, echocardiographic findings normalized, and medical treatment was gradually discontinued. To date, the cat remains healthy at 1735 days after the initial diagnosis and 1494 days after the last antithrombotic medication. To the best of our knowledge, this is the first case report on feline arterial thromboembolism combined with transient myocardial thickening, with favorable long-term survival.Item type: Item , Individual differences in internal models explain idiosyncrasies in scene perception(2024) Wang, Gongting; Foxwell, Matthew J.; Cichy, Radoslaw M.; Pitcher, David; Kaiser, DanielAccording to predictive processing theories, vision is facilitated by predictions derived from our internal models of what the world should look like. However, the contents of these models and how they vary across people remains unclear. Here, we use drawing as a behavioral readout of the contents of the internal models in individual participants. Participants were first asked to draw typical versions of scene categories, as descriptors of their internal models. These drawings were converted into standardized 3d renders, which we used as stimuli in subsequent scene categorization experiments. Across two experiments, participants' scene categorization was more accurate for renders tailored to their own drawings compared to renders based on others' drawings or copies of scene photographs, suggesting that scene perception is determined by a match with idiosyncratic internal models. Using a deep neural network to computationally evaluate similarities between scene renders, we further demonstrate that graded similarity to the render based on participants' own typical drawings (and thus to their internal model) predicts categorization performance across a range of candidate scenes. Together, our results showcase the potential of a new method for understanding individual differences – starting from participants' personal expectations about the structure of real-world scenes.Item type: Item , 3-spherical twin buildings(2024) Bischof, SebastianWe classify thick irreducible 3-spherical twin buildings of rank at least 3 in which every panel contains at least 6 chambers. Together with the Main result of [11] we obtain a classification of thick irreducible 3-spherical twin buildings.Item type: Item , Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction(2024) Schraps, Nina; Tirre, Michaela; Pyschny, Simon; Reis, Anna; Schlierbach, Hannah; Seidl, Matthias; Kehl, Hans-Gerd; Schänzer, Anne; Heger, Jacqueline; Jux, Christian; Drenckhahn, Jörg-DetlefCardiomyocyte maturation during pre- and postnatal development requires multiple intertwined processes, including a switch in energy generation from glucose utilization in the embryonic heart towards fatty acid oxidation after birth. This is accompanied by a boost in mitochondrial mass to increase capacities for oxidative phosphorylation and ATP generation required for efficient contraction. Whether cardiomyocyte differentiation is paralleled by augmented capacities to deal with reactive oxygen species (ROS), physiological byproducts of the mitochondrial electron transport chain (ETC), is less clear. Here we show that expression of genes and proteins involved in redox homeostasis and protein quality control within mitochondria increases after birth in the mouse and human heart. Using primary embryonic, neonatal and adult mouse cardiomyocytes in vitro we investigated how excessive ROS production induced by mitochondrial dysfunction affects cell survival and stress response at different stages of maturation. Embryonic and neonatal cardiomyocytes largely tolerate inhibition of ETC complex III by antimycin A (AMA) as well as ATP synthase (complex V) by oligomycin but are susceptible to complex I inhibition by rotenone. All three inhibitors alter the intracellular distribution and ultrastructure of mitochondria in neonatal cardiomyocytes. In contrast, adult cardiomyocytes treated with AMA undergo rapid morphological changes and cellular disintegration. At the molecular level embryonic cardiomyocytes activate antioxidative defense mechanisms, the integrated stress response (ISR) and ER stress but not the mitochondrial unfolded protein response upon complex III inhibition. In contrast, adult cardiomyocytes fail to activate the ISR and antioxidative proteins following AMA treatment. In conclusion, our results identified fundamental differences in cell survival and stress response in differentiated compared to immature cardiomyocytes subjected to mitochondrial dysfunction. The high stress tolerance of immature cardiomyocytes might allow outlasting unfavorable intrauterine conditions thereby preventing fetal or perinatal heart disease and may contribute to the regenerative capacity of the embryonic and neonatal mammalian heart.Item type: Item , Microbiological quality of raw beef imported into the European Union from third countries(2024) Rinn, Nicola; Braun, Ann-Sophie; Müller, Anja; Wadepohl, Katharina; Gerulat, Bettina; Kumm, Franziska; Yue, Min; Kehrenberg, CorinnaRaw beef imported into the European Union (EU) from third countries must fulfill the same legal requirements as products from EU member states. Recently, the microbiological quality of 100 raw beef samples imported from third countries into the EU was investigated. Samples were quantitatively analyzed according to DIN ISO standard methods for aerobic mesophilic colony counts (ACC), counts of Enterobacteriaceae, Escherichia coli, Listeria monocytogenes, coagulase-positive staphylococci and qualitatively for L. monocytogenes and Salmonella spp. Samples were also screened for the presence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and Shiga toxin-producing E. coli (STEC). Detected STEC isolates were subjected to whole genome sequencing. An E. coli prevalence of 3 % was detected, with one sample exceeding the critical value of the German Society for Hygiene and Microbiology (DGHM). Coagulase-positive staphylococci were found in one sample, but at a level below the DGHM guidance value. In three samples, L. monocytogenes were detected quantitatively, but none of these surpassed the critical value. Salmonella spp. were not detected, but Enterobacteriaceae were present in 83 % of the samples, of which 40 % surpassed the critical value. Combined with detected high values of ACC, this may indicate hygiene deficiencies. Additionally, STEC-screening showed a prevalence of 2 % and both STEC isolates harbored stx1 and stx2. Overall, the occurrence of foodborne pathogens in the samples analyzed was low, but DGHM requirements for raw beef were not completely fulfilled. In combination with the detection of STEC, this may represent a potential health hazard for consumers.