Welcome to JLUpub

Communities in JLUpub

Select a community to browse its collections.

Now showing 1 - 2 of 2

JLUdata
Forschungsdatenrepositorium
JLUdocs
Schriftenrepositorium

Recent Submissions

Soluble urokinase plasminogen activator receptor (suPAR) plasma concentration is reduced using minimized extracorporeal circulation : results of a secondary analysis of a prospective observational study
(2025) Zajonz, Thomas S.; Edinger, Fabian; Götze, Juliane; Markmann, Melanie; Sander, Michael; Koch, Christian; Schneck, Emmanuel
Background: Minimized extracorporeal circulation (miECC) was developed to mitigate the adverse effects of cardiopulmonary bypass (CPB), yet its impact on soluble Urokinase plasminogen activator receptor (suPAR) is unclear. SuPAR has been linked to adverse outcomes, including acute kidney injury (AKI). This study investigated perioperative suPAR kinetics in patients undergoing cardiac surgery with miECC or conventional CPB (cCPB) and explored its association with AKI, postoperative delirium (POD), and infections. Methods: This study is a secondary analysis of an observational cohort of 79 cardiac surgical patients. It evaluates perioperative suPAR levels and their association with the type of CPB used (miECC vs. cCPB) and postoperative adverse outcomes, including POD, AKI, and infections. Statistical analyses included repeated measures ANOVA, Wilcoxon tests, logistic regression, and ROC curve analysis to assess the predictive value of suPAR for these outcomes. Results: During surgery, suPAR significantly increased to higher Levels with the use of cCPB compared to miECC (p = 0.027; odds ratio of 0.69 [0.57–0.84], p < 0.001). The use of miECC was an independent influencing factor on suPAR (−0.41 ± 0.1; p < 0.001). Regardless of the type of CPB, suPAR levels differed significantly between patients with and without kidney damage (n = 25; no AKI: 1.6 [1.1–2.0], AKI: 1.7 [1.3–2.4], p < 0.001). Multivariate regression analysis showed that AKI was an independent influencing factor on suPAR (−0.49 ± 0.1; p < 0.001). SuPAR demonstrated only low predictive value for AKI and could not predict POD. Conclusions: This study provides evidence that miECC is associated with lower intraoperative suPAR levels, suggesting a reduced inflammatory response compared to cCPB. While suPAR levels were significantly higher in patients with AKI, their predictive value for AKI remains limited. Furthermore, suPAR did not predict POD but was elevated in patients with pneumonia.
Diabetes-related distress and psychological burden in patients with type 1 and type 2 diabetes – the role of child maltreatment, personality functioning, and epistemic trust: findings from a German clinical inpatient sample
(2025) Zara, Sandra; Ullrich, Imogen Carla; Leveling, Anna Maria; Saretzki, Friederike Gisela Genoveva; Schmitz, Jana; Eckhard, Michael; Kruse, Johannes; Kampling, Hanna
Patients with diabetes exhibit high frequencies of psychological burden and diabetes-related distress. Child maltreatment has been independently linked to both diabetes and psychological burden. We aimed 1) to explore the association between child maltreatment and diabetes-related distress, and between child maltreatment and psychological burden, and 2) to investigate the mediating role of personality functioning (psychological abilities with regard to the self and others) in this association. We included epistemic trust (openness for social learning) and its impairments mistrust (the tendency to consider information sources as unreliable or ill-intended) and credulity (lack of vigilance and discrimination between trustworthy and untrustworthy information) as covariates.
Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon
(2025) Zheng, Ying; Moorlach, Benjamin; Jakobs-Schönwandt, Desiree; Patel, Anant; Pastacaldi, Chiara; Jacob, Stefan; Sede, Ana R.; Heinlein, Manfred; Poranen, Minna M.; Kogel, Karl-Heinz; Ladera Carmona, Maria
In vertebrates and plants, dsRNA plays crucial roles as PAMP and as a mediator of RNAi. How higher fungi respond to dsRNA is not known. We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad size range of 21 to about 3000 bp. Incubation of fungal conidia with 10 ng/μL dsRNA, regardless of size or sequence, induced aberrant germ tube elongation, revealing a strong sequence-unspecific effect of dsRNA in this fungus. Accordingly, the synthetic dsRNA analogue poly(I:C) and dsRNA of various sizes and sequences elicited canonical fungal stress pathways, including nuclear accumulation of the stress marker mitogen-activated protein kinase Hog1p and production of ROS. Leaf application of dsRNA to the cereal model species Brachypodium distachyon suppressed the progression of leaf blast disease. Notably, the sequence-unspecific effect of dsRNA depends on higher doses, while pure sequencespecific effects were observed at low concentrations of dsRNA ( < 0.03 ng/μL). The protective effects of dsRNA were further enhanced by maintaining a gap of at least seven days between dsRNA application and inoculation, and by stabilising the dsRNA in alginate-chitosan nanoparticles. Overall, our study opens up additional possibilities for the development and use of dsRNA pesticides in agriculture.
The impact of grazing and fertilization intensity on functional trait diversity and assembly processes of soil mesofauna in grasslands
(2026) Baulechner, Dennis; John, Katharina; Zaitsev, Andrey; Saifutdinov, Ruslan; Wolters, Volkmar
C atoms versus Si atoms at the bridgehead positions of phenyl-decorated adamantane-type clusters: influence on the nonlinear optical response
(2026) Ziese, Ferdinand; Dehnen, Stefanie; Sanna, Simone
In order to explore the effect of the presence of CPh versus SiPh parts on the optical nonlinearities of phenyl-decorated adamantane-type clusters, the second harmonic generation (SHG) spectra of molecular clusters with the general formula [(CPh)x(SiPh)4−xS6] and x = 0,…, 4, are calculated within (hybrid) density functional theory. The stepwise replacement of C atoms with Si at the bridgehead positions leads to the blue-shift of the first SHG peak and to a redistribution of the spectral weights of the different signatures. The electronic transitions related to the SHG peaks are found to occur mainly at the substituents, which are common to all investigated compounds. However, the peak intensity strongly depends on the substitution induced distortion of the cluster core. Thus, although the cluster core is not directly involved in the genesis of the optical nonlinearities, it heavily impacts their intensity. The presented results suggest that reducing the core symmetry provides a pathway to enhance the SHG response of the clusters and yields a theoretical foundation for the design of nonlinear optical materials with tailored properties.