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Depression and somatization in Turkish migrants in Germany : the role of migration-related stressors
(2025) Hanewald, Bernd; Hahn, Eric; Ta, Tam Thi Minh; Elguen, Yasemin; Stingl, Markus
Introduction: Migration-related stressors (MRS), such as loss, cultural conflict, and language barriers, are linked to increased psychological distress. This study investigates the impact of MRS on de-pressive symptoms and somatization among Turkish-speaking first-generation migrants in Germany. Method: In a cross-sectional study, 60 psychiatric outpatients completed standardized measures as-sessing MRS, depressive symptoms (BDI-II), and somatization (PHQ-15). Regression analy-ses controlled for age, gender, and socioeconomic status. Results: Higher MRS significantly predicted both depressive symptoms and somatization. Somatic complaints were particularly associated with language difficulties, separation experiences, and intergenerational value conflicts. Conclusion: Findings support the need to integrate cultural humility—defined as clinician self-awareness, openness, and contextual sensitivity—into evidence-based care. Symptom interpretation must consider patients’ migration histories and cultural frameworks. Culturally adapted, person-centered interventions may improve diagnostic accuracy and treatment outcomes for migrant populations.
sORFdb – a database for sORFs, small proteins, and small protein families in bacteria
(2025) Hahnfeld, Julian M.; Schwengers, Oliver; Jelonek, Lukas; Diedrich, Sonja; Cemic, Franz; Goesmann, Alexander
The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion proteins and biotin tagging, we identify >350 RELA interactors from untreated and IL-1α-stimulated cells, including many TFs (47% of all interactors) and >50 epigenetic regulators belonging to different classes of chromatin remodeling complexes. A comparison with the interactomes of two point mutants of p65 reveals that the interactions primarily require intact dimerization rather than DNA-binding properties. A targeted RNAi screen for 38 interactors and subsequent functional transcriptome and bioinformatics studies identify gene regulatory (sub)networks, each controlled by RELA in combination with one of the TFs ZBTB5, GLIS2, TFE3/TFEB, or S100A8/A9. The large, dynamic and versatile high-resolution interactome of RELA and its gene regulatory logics provides a rich resource and a new framework for explaining how RELA cooperativity determines gene expression patterns.
Transmissible Staphylococcus pseudintermedius thwarts neutrophil extracellular trap-driven containment to promote invasive disease
(2025) Haller, Rita; Cai, Yiyang; de Buhr, Nicole; Rieder, Johanna C.; Schlüter, Dirk; Baier, Claas; Rohde, Holger; von Köckritz-Blickwede, Maren; Vital, Marius; Winstel, Volker
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging zoonotic pathogen that causes a variety of clinical diseases in mammalian hosts. While it frequently causes infections in dogs and other domestic animals, accumulating evidence indicates that zoonotic spillover and cross-species transmission events favour local and invasive S. pseudintermedius infections in humans. However, immuno-evasive maneuvers that shape S. pseudintermedius pathogenicity and survival in diseased hosts remain enigmatic. Powered by multi-tech imaging and a mouse model of bloodstream infection, we illustrate that S. pseudintermedius adopted a virulence mechanism from predominant bacterial pathogens to surmount neutrophilic responses and neutrophil extracellular trap (NET)-mediated killing. Specifically, release of NucB, a thermostable nuclease, helps MRSP coping with the antimicrobial and pathogen-immobilizing properties of NETs and even promotes intra-neutrophil survival upon phagocytosis, thereby contributing to S. pseudintermedius pathogenesis and persistence within hepatic abscesses. Combined with the analysis of genetically distinct human clinical isolates, all of which display nuclease activity and features of resistance to NETosis-induced killing, our data highlight how zoonotic staphylococci overcome innate immune responses and concurrently uncover a mechanism that may exacerbate animal-borne MRSP infections in humans.
Identification of innovation drivers based on technology-related news articles
(2025) Latifi, Albina; Lenz, David; Winker, Peter
Innovations contribute to economic growth. Hence, knowledge about drivers of innovation activities is a necessary input for economic policy making when it comes to implement targeted support measures. We focus on firms as potential drivers of innovation and use a novel data-driven approach to identify them. The approach is based on news articles from a technology-related newspaper for the period 1996–2021. In a first step, natural language processing (NLP) tools are used to identify latent topics in the text corpus. Expert knowledge is used to tag innovation-related topics. In a second step, a named entity recognition (NER) method is used to detect firm names in the news articles. Combining the information about innovation-related topics and firms mentioned in news articles linked to these topics provides a set of firms linked to each innovation-related topic. For each entity (firm), we identify the specific innovation fields in which it is involved. Similarly, for each innovation field, we determine the companies that are driving innovation within that area. The results suggest that the approach helps identifying drivers of innovation activities going beyond the usual suspects. However, given that the rate of false alarms is not negligible, at the end also human judgement is needed when using this approach.
Quantifying preferential flow occurrence in dependence of land cover on the southern slopes of Mount Kilimanjaro, Tanzania
(2025) Shagega, Frank Paul; Codalli, Fabia; Jacobs, Suzanne; Munishi, Subira Eva; Windhorst, David; Breuer, Lutz
Study regions: This study examined preferential flow occurrence and patterns in eight ecosystem types on the southern slopes of Mount Kilimanjaro in Tanzania. Study Focus: We analyzed continuous soil moisture content measured in three soil depths and rainfall data at 1-h resolution from January 2022 to August 2023. After a separation and clustering of rainfall events we assessed the dynamics of soil moisture responses. The sequence and timing of soil moisture changes informed about the occurrence of preferential versus sequential (matrix) flow. New hydrological insights for the Region: The results showed that the frequency of occurrence of preferential flow events were notably high in Erica forest (81.6 %), montane forest (26.4 %), and Ocotea forest (30.1 %), highlighting rapid subsurface water movement and potential for groundwater recharge. Other land covers such as disturbed Ocotea forest, grassland and maize indicated more uniform flow dynamics, which may favor surface runoff and increased soil erosion. We found that rainfall depth, duration and intensity are important factors that influence preferential flow. Additionally, the level of initial soil moisture also played a role in preferential flow occurrence, with optimal initial soil moisture levels between 35 % and 45 %. Both, very dry and very wet soil conditions were less favorable for preferential flow occurrence. These findings have important implications for understanding subsurface water movements and managing water resources in both natural and disturbed ecosystems.