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JLUpub ist das institutionelle Repositorium der Justus-Liebig-Universität.
JLUpub bietet Mitgliedern und Angehörigen der Universität die Möglichkeit neben wissenschaftlichen Dokumenten auch Forschungsdaten elektronisch zu veröffentlichen und dauerhaft zugänglich zu machen. Alle Veröffentlichungen erhalten einen Digital Object Identifier (DOI) und werden über nationale und internationale Bibliothekskataloge sowie Suchmaschinen nachgewiesen und auffindbar.
Neue Veröffentlichungen:
Xammlung – Antike Objekte treffen auf zeitgenössische Perspektiven
(2025) Künstlergruppe Guirlanden
Am 09. Oktober 2025 eröffnet die dänische KünstlerInnengruppe Guirlanden in Kooperation mit der Antikensammlung der JLU Gießen eine experimentelle Kunstausstellung, die antike Objekte mit zeitgenössischer Kunst in Dialog setzt. Die Ausstellung lädt BesucherInnen ein, die Antike in modernen Rezeptionen und unterschiedlichen Medien neu zu entdecken. Das „X“ im Titel symbolisiert dabei die Schnittstelle, an der Antike und Moderne aufeinandertreffen: historische Objekte und aktuelle Sichtweisen treten in Wechselwirkung und eröffnen neue Perspektiven über die Grenzen von Zeit, Medium und Interpretation hinweg.
Die ortsspezifischen Werke der KünstlerInnen greifen zentrale Themen der antiken Kunst und Kultur auf – von Alphabet, Architektur und Kleidung über Theater und Metamorphose bis hin zu Fragmentierung, Skulptur und Zeit. Mit Materialien wie Keramik, Tusche, Stoff, Lichtprojektionen, Fotografie, Klang, 3D-Scans und digitalen Medien wie ChatGPT werden diese Themen neu interpretiert und in die Gegenwart transportiert.
Ausstellung basiert auf Objekten der Antikensammlung der Justus-Liebig-Universität Gießen. Mit über 5.000 Artefakten – darunter Vasen, Terrakotten, Reliefs, Statuetten, Münzen und römische Gläser – vermittelt die Sammlung, von der eine repräsentative Auswahl im Museum für Gießen in wechselnden Sonderausstellungen öffentlich präsentiert wird, Einblicke in rund 3.000 Jahre antiker Kultur: von Götterwelt, Theater und Bestattungssitten bis hin zu Schriftkultur und Alltagsleben. Bedeutende Wissenschaftlerinnen wie Margarete Bieber, Pionierin der antiken Theater- und Trachtenforschung, prägten die Sammlungsgeschichte. In der Ausstellung werden Objekte der Sammlung zum Teil in Form von 3D-Replikaten Bestandteile der neu geschaffenen Kunstwerke.
Opportunistic Acinetobacter baumannii and Acinetobacter sp. Isolates in Rural and Urban Wastewater Treatment Plants and Raw Manure and Biogas Digestates
(2025) Pulami, Dipen
Genus Acinetobacter is diverse, and multi-drug resistant (MDR) Acinetobacter linked infections are problematic. Studies hitherto performed in extra-clinical settings, such as biogas plants (BGPs) and wastewater treatment plants (WWTPs), lacked diversity and antimicrobial resistance (AMR) of Acinetobacter. This thesis studied the diversity and AMR of Acinetobacter in livestock manure, BGP digestates, a rural WWTP, and two urban WWTPs (receiving hospital/veterinary sewage), including upstream/downstream from the river receiving effluent located in Germany. Partial 16S rRNA/rpoB genes-based study showed highest diversity (8/14, phylotypes) in urban WWTPs influent. A. baumannii were found in manure, digestate and all stages of rural WWTP (except river upstream). BGPs and rural WWTP had novel sequence-types (18/23, STs) susceptible to antimicrobials—indicating these niches consisted diverse Acinetobacter. In urban WWTPs, Acinetobacter were also isolated from secondary sludge and anaerobic post-digestor filtrate, and mostly showed MDR phenotypes against carbapenems, colistin and ciprofloxacin, suggesting hospital waste inflow into WWTPs influenced their AMR profile and clinical relevance. Isolation of Acinetobacter from digestate, and treated sludge/anaerobic post-digestor filtrate indicated their survival in anaerobic condition, which was supported by the presence of genes encoding AMP phosphotransferase and adenylate kinase linked to processing of polyphosphates for energy. Comparative genomics of A. bohemicus strains from pig manure (QAC-21b, this study) and textile dying pond (KCTC 42081, Abbas et al. 2014) showed higher genomic contents of transposons/insertion elements, and genomic islands suggesting their adaptation to these environments containing quaternary alkyl ammonium compounds (QAACs), compared to type strain ANC 3994T (forest soil, Krizova et al. 2014). Considering Acinetobacter genome plasticity, the likelihood of selection/spread of AMR if released into environment via manure (sludge) must not be neglected. Experiments with Acinetobacters from various sources will help understand this process. Plant colonization study can provide insights into potential interactions in the rhizosphere and phyllosphere, revealing routes of Acinetobacter transmission to humans. Taking “One-Health” approach, future Acinetobacter genome comparison from different sources might help understanding evolution and adaptation from extra-clinical to clinical settings. This could help development of intervention strategies to control AMR spread in non-clinical environments.
uniforum 38 (2025) Nr. 3
(2025)
Wie sieht eine Allianz für Demokratie aus? Wie stellt sich die JLU für die Zukunft auf? Wie LOEWEnstark ist gemeinsame Forschung und wie breit sind die Themen gefächert? Wie wurde Gießen einst eine Brücke zur Freiheit und wie sind Studierende heute im Lern- und Erinnerungsort Notaufnahmelager aktiv? Wie überzeugen zwei Lehramtsstudentinnen mit einem Planspiel zum Thema One Health im Biologieunterricht?
Diese und viele weitere Informationen rund um Ereignisse und Entwicklungen an der JLU lesen Sie in der aktuellen Ausgabe des uniforum.
Illiberal SCRIPTS Dataset: Corpus-Based Analysis of Norm Diffusion across Post-Soviet Regional Organisations (CIS, CSTO, SCO)
(2025) Nasibov, Murad; Gawrich, Andrea
This dataset accompanies the book chapter "Scripts in Circulation: Cross-Pollination of Anti-Liberal Norms in Eurasian Regionalism" (Gawrich & Nasibov, In: Panke, Diana; Libman, Alexander; Börzel, Tanja: Contestations of the Liberal Script in Regional Organizations in the Global South and the Global North. Oxford University Press (Forthcoming)).
It provides all reproducible analytical artefacts derived from declaratory documents of three intergovernmental organisations – the Commonwealth of Independent States (CIS), the Collective Security Treaty Organisation (CSTO), and the Shanghai Cooperation Organisation (SCO) – covering the period 2002–2024.
The dataset excludes verbatim text for copyright reasons and instead offers fully processed linguistic and statistical representations that enable complete replication of the study’s computational findings.
The analysis conceptualises “script cross-pollination” as the diffusion of illiberal normative vocabularies – such as sovereignty, stability, multipolarity, and non-interference – across regional organisations in post-Soviet Eurasia.
Using a transparent R-based pipeline, the study lemmatises and tokenises Russian-language summit declarations, constructs document–feature matrices and TF–IDF representations, and computes time-series trends, inter-organisational cosine similarity, and lead–follow diffusion patterns.
The dataset demonstrates how illiberal normative repertoires migrate, stabilise, and co-evolve across Eurasian organisations, showing that these institutions function as discursive relay stations of a shared counter-liberal script rather than as isolated challengers of liberal order.
All processing and analytical steps are documented in the included file illiberal_scripts_pipeline_public.R and further explained in HOW_TO_USE_outputs_README.md.
Contents
File - Description
illiberal_scripts_pipeline_public.R - Full R code for reproducing the analysis pipeline (CC-BY-NC).
HOW_TO_USE_outputs_README.md - Documentation of data structure and usage.
step02_dfm_lemmas.rds - Lemma-level document–feature matrix.
step02_dfm_lemmas_aligned.rds - Lemma DFM aligned with metadata.
step02_dfm_tfidf_lemmas.rds - TF–IDF weighted lemma matrix.
step02_dfm_bigrams.rds - Bigram-level DFM (2-word combinations).
step03_freq_illiberal_terms.csv - Yearly frequency of illiberal dictionary terms (CIS/CSTO/SCO).
step03_crosspollination_similarity.csv - Cosine similarity between organisations by year.
step03_first_use_by_org.csv - First observed use of each lemma by organisation.
step03_adoptions_with_origin.csv - Term diffusion trajectories (origin → adopter + lag).
step03_influence_edges_lag3.csv - Aggregated influence edges within a 3-year window.
Eosinophil proteins and their role during filarial infection
(2025) Schumacher, Pia Philippa
In the current work, the role of eosinophil effector proteins in filarial infections was investigated. It focused on how eosinophils contribute to the immobilization and elimination of MF through both the formation of extracellular DNA traps (ETosis) and the release of granule proteins – in particular MBP and EPO. Using mouse models, including KO mice for MBP and EPO, and comparisons with natural hosts (cotton rats), it was shown that these proteins are crucial for inhibiting MF motility and contribute significantly to eosinophil-mediated parasite control.
Another focus of the current work was the immunomodulatory function of eosinophils, particularly through the production of IL-4. The study demonstrated that eosinophils represent an essential and early source of IL-4 during infection with L. sigmodontis, thereby acting as potent initiators and amplifiers of type 2 immune responses. Although alternative macrophage activation could be maintained without eosinophils, their presence was crucial for effective Th2 polarisation, as evidenced by the reduced number of CD4⁺ T cells and lower levels of IL-5 and IL-13 in eosinophil-deficient dblGATA mice. This highlights the non-redundant role of eosinophil-derived IL-4 in the establishment of a functional Th2 milieu, which could not be compensated by other IL-4-producing cells such as ILC2s or Th2 cells.
In addition, this work addressed possible mechanisms of IL-4 induction in eosinophils, pointing to epithelial-derived alarmins (IL-33, IL-25, TSLP) and helminth components sensed via PRRs (e.g. TLR7, Dectin-1) as potential triggers. Transcriptional regulators such as STAT6, GATA-1 and NFAT were identified as candidates in the regulation of IL-4 production in eosinophils, although these mechanisms require further elucidation.
One interesting aspect of the study was the comparison of L. sigmodontis infections in a mouse model and the natural host, the cotton rat (Sigmodon hispidus). It was found that eosinophils of cotton rats are less effective in immobilizing MF than those of mice. This observation suggests host-specific adaptations of the parasite, potentially involving immune evasion strategies targeting eosinophil function, such as suppression of IL-4 production or resistance to ETosis.
Finally, the translational implications of these results were underpinned by further findings of the working group showing that eosinophil-driven type 2 immunity can exert beneficial metabolic effects. L. sigmodontis infection and LsAg administration improved glucose tolerance and insulin sensitivity in diet-induced obese mice in an eosinophil-dependent manner, especially in adipose tissue, where eosinophils support the maintenance of alternatively activated macrophages.
In summary, the present dissertation provides new insights into the dual role of eosinophils: on the one hand, they act as direct effector cells that contribute to parasite control via ETosis and cytotoxic granule proteins (MBP, EPO) and on the other hand, they emerge as critical immunoregulatory cells through their early and localized production of IL-4, shaping the adaptive Th2 response. These findings contribute to a better understanding of the complex interplay between host and parasite and could enable new therapeutic approaches against filarial infections in the future.