Browsing by Author "Padberg, Winfried"
Now showing items 1-20 of 32
-
Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1ß release by mononuclear phagocytes
Richter, Katrin; Asci, Nilay; Singh, Vijay K.; Yakoob, Sanaria Hawro; Meixner, Marion; Zakrzewicz, Anna; Liese, Juliane; Hecker, Andreas; Wilker, Sigrid; Stumpf, Sabine; Schlüter, Klaus-Dieter; Rohde, Marius; Gödecke, Axel; Padberg, Winfried; Manzini, Ivan; Schmalzing, Günther; Grau, Veronika (2023)Objective: The pro-inflammatory cytokine interleukin-1β (IL-1β) plays a central role in host defense against infections. High systemic IL-1β levels, however, promote the pathogenesis of inflammatory disorders. Therefore, ... -
Activation of Humoral Immunity during the Pathogenesis of Experimental Chronic Lung Allograft Dysfunction
Reichert, Martin; Atanasova, Srebrena; Petri, Kathrin; Kampschulte, Marian; Kojonazarov, Baktybek; Fuchs-Moll, Gabriele; Krombach, Gabriele A.; Padberg, Winfried; Grau, Veronika (2022) -
Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1beta via CD36 and Nicotinic Acetylcholine Receptors
Siebers, Kathrin; Fink, Bijan; Zakrzewicz, Anna; Agne, Alisa; Richter, Katrin; Konzok, Sebastian; Hecker, Andreas; Zukunft, Sven; Küllmar, Mira; Klein, Jochen; McIntosh, J. Michael; Timm, Thomas; Sewald, Katherina; Padberg, Winfried; Aggarwal, Nupur; Chamulitrat, Walee; Santoso, Sentot; Xia, Wendy; Janciauskiene, Sabina; Grau, Veronika (2018)While interleukin (IL)-1beta is a potent pro-inflammatory cytokine involved in host defense, high levels can cause life-threatening sterile inflammation including systemic inflammatory response syndrome. Hence, the control ... -
Amyloid Beta Peptide (Aß1-42) Reverses the Cholinergic Control of Monocytic IL-1ß Release
Richter, Katrin; Ogiemwonyi-Schaefer, Raymond; Wilker, Sigrid; Chaveiro, Anna I.; Agne, Alisa; Hecker, Matthias; Reichert, Martin; Amati, Anca-Laura; Schlüter, Klaus-Dieter; Manzini, Ivan; Schmalzing, Günther; McIntosh, J. Michael; Padberg, Winfried; Grau, Veronika; Hecker, Andreas (2020) -
Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation
Edinger, Fabian; Schmitt, Christoph; Koch, Christian; McIntosh, J. Michael; Janciauskiene, Sabina; Markmann, Melanie; Sander, Michael; Padberg, Winfried; Grau, Veronika (2021) -
beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells
Hiller, Sebastian Daniel; Heldmann, Sarah; Richter, Katrin; Jurastow, Innokentij; Küllmar, Mira; Hecker, Andreas; Wilker, Sigrid; Fuchs-Moll, Gabriele; Manzini, Ivan; Schmalzing, Günther; Kummer, Wolfgang; Padberg, Winfried; McIntosh, J. Michael; Damm, Jelena; Zakrzewicz, Anna; Grau, Veronika (2018)While interleukin-1beta (IL-1beta) is a potent pro-inflammatory cytokine essential for host defense, high systemic levels cause life-threatening inflammatory syndromes. ATP, a stimulus of IL-1beta maturation, is released ... -
C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation
Richter, Katrin; Sagawe, Sabrina; Hecker, Andreas; Küllmar, Mira; Askevold, Ingolf; Damm, Jelena; Heldmann, Sarah; Pöhlmann, Michael; Ruhrmann, Sophie; Sander, Michael; Schlüter, Klaus-Dieter; Wilker, Sigrid; König, Inke R.; Kummer, Wolfgang; Padberg, Winfried; Hone, Arik J.; McIntosh, J. Michael; Zakrzewicz, Anna Teresa; Koch, Christian; Grau, Veronika (2018)Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions of CRP are still controversial. CRP is a phosphocholine (PC)-binding ... -
Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1ß via Different Combinations of Nicotinic Acetylcholine Receptor Subunits a7, a9 and a10
Zakrzewicz, Anna; Richter, Katrin; Agné, Alisa; Wilker, Sigrid; Siebers, Kathrin; Fink, Bijan; Krasteva-Christ, Gabriela; Althaus, Mike; Padberg, Winfried; Hone, Arik J.; McIntosh, J. Michael; Grau, Veronika (2017)Recently, we discovered a cholinergic mechanism that inhibits the ATP-dependent release of interleukin-1ß (IL-1ß) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of a7, a9 and/or a10 subunits. ... -
A case report of acute pulmonary hypertension after hyperthermic intraperitoneal chemotherapy (HIPEC) and review of the literature
Zajonz, Thomas S.; Sander, Michael; Padberg, Winfried; Hecker, Andreas; Hörbelt, Ruediger; Koch, Christian; Schneck, Emmanuel (2018)Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) poses a widely used and accepted treatment option for patients with peritoneal carcinomatosis of gastrointestinal tumors. In contrast to the well-described risks ... -
Caspase-Cleaved Keratin 18 Measurements Identified Ongoing Liver Injury after Bariatric Surgery
Hempel, Felix; Roderfeld, Martin; Müntnich, Lucas John; Albrecht, Jens; Oruc, Ziya; Arneth, Borros; Karrasch, Thomas; Pons-Kühnemann, Jörn; Padberg, Winfried; Renz, Harald; Schäffler, Andreas; Roeb, Elke (2021) -
Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1ß by Monocytic Cells
Amati, Anca-Laura; Zakrzewicz, Anna; Siebers, Kathrin; Wilker, Sigrid; Heldmann, Sarah; Zakrzewicz, Dariusz; Hecker, Andreas; McIntosh, J. Michael; Padberg, Winfried; Grau, Veronika (2017)Chemokines and ATP are among the mediators of inflammatory sites that can enter the circulation via damaged blood vessels. The main function of chemokines is leukocyte mobilization, and ATP typically triggers inflammasome ... -
Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP
Richter, Katrin; Papke, Roger L.; Stokes, Clare; Roy, Danika C.; Espinosa, Eduardo S.; Wolf, Philipp M. K.; Hecker, Andreas; Liese, Juliane; Singh, Vijay K.; Padberg, Winfried; Schlüter, Klaus-Dieter; Rohde, Marius; McIntosh, J. Michael; Morley, Barbara J.; Horenstein, Nicole A.; Grau, Veronika; Simard, Alain R. (2022) -
Drug resistant bacteria in perianal abscesses are frequent and relevant
Bender, Fabienne; Eckerth, Lukas; Fritzenwanker, Moritz; Liese, Juliane; Askevold, Ingolf; Imirzalioglu, Can; Padberg, Winfried; Hecker, Andreas; Reichert, Martin (2022) -
Frailty in elderly patients with acute appendicitis
Reinisch, Alexander; Reichert, Martin; Ondo Meva, Christian Charles; Padberg, Winfried; Ulrich, Frank; Liese, Juliane (2022) -
The impact of early surgical intervention in free intestinal perforation: a time-to-intervention pilot study
Hecker, Andreas; Schneck, Emmanuel; Röhrig, Rainer; Roller, F.; Hecker, B.; Holler, J.; Koch, C.; Hecker, M.; Reichert, M.; Lichtenstern, C.; Krombach, G.; Padberg, Winfried; Weigand, M. A. (2015)PURPOSES: An abdominal inflammatory focus is the second most often source of sepsis with a high risk of death in surgical intensive care units. By establishing evidence-based bundled strategies the surviving sepsis campaign ... -
Impact of the SARS-CoV-2 pandemic on emergency surgery services - a multi-national survey among WSES members
Reichert, Martin; Sartelli, Massimo; Weigand, Markus A.; Doppstadt, Christoph; Hecker, Matthias; Reinisch-Liese, Alexander; Bender, Fabienne; Askevold, Ingolf Harald; Padberg, Winfried; Coccolini, Federico; Catena, Fausto; Hecker, Andreas (2020) -
Integrative Medizin in der palliativen Onkologie – Eine deskriptive retrospektive Kohortenstudie zur Überlebenszeitanalyse
Balser, Dorothe (2021)Komplementäre Therapien werden in der Onkologie sehr kontrovers diskutiert. Ein Mangel an klinischen Studien trägt zu dieser Situation bei. Oftmals werden komplementäre Therapien mit alternativen Therapien verwechselt, die ... -
Intravenous immunoglobulin in necrotizing fasciitis : a case report and review of recent literature
Koch, Christian; Hecker, Andreas; Grau, Veronika; Padberg, Winfried; Wolff, Matthias; Henrich, Michael (2015)Introduction: Necrotizing fasciitis (NF) is an inflammatory disease of the soft tissue, which causes local tissue destruction and can lead to lethal septic shock. The therapy consists of early surgical treatment of the ... -
Ivor Lewis esophagectomy patients are particularly vulnerable to respiratory impairment - a comparison to major lung resection
Reichert, Martin; Schistek, Magdalena; Uhle, Florian; Koch, Christian; Bodner, Johannes; Hecker, Matthias; Hörbelt, Rüdiger; Grau, Veronika; Padberg, Winfried; Weigand, Markus A.; Hecker, Andreas (2019) -
Lung decortication in phase III pleural empyema by video-assisted thoracoscopic surgery (VATS) : results of a learning curve study
Reichert, Martin; Pösentrup, Bernd; Hecker, Andreas; Padberg, Winfried; Bodner, Johannes (2018)Background: Pleural empyema (PE) is a devastating disease with a high morbidity and mortality. According to the American Thoracic Society it is graduated into three phases and surgery is indicated in intermediate phase II ...