Willkommen bei JLUpub
JLUpub ist das institutionelle Repositorium der Justus-Liebig-Universität.
JLUpub bietet Mitgliedern und Angehörigen der Universität die Möglichkeit neben wissenschaftlichen Dokumenten auch Forschungsdaten elektronisch zu veröffentlichen und dauerhaft zugänglich zu machen. Alle Veröffentlichungen erhalten einen Digital Object Identifier (DOI) und werden über nationale und internationale Bibliothekskataloge sowie Suchmaschinen nachgewiesen und auffindbar.
Neue Veröffentlichungen:
Item type: Item , Inkjet-printed quantum dots on paper as concept towards high-density long-term data storage(2024) Mengel, Nils; Welzel, Marius; Niedenthal, Woldemar; Stein, Markus; Heider, Dominik; Chatterjee, SangamHandling and storing the immense amounts of data native to the information age is a major challenge in terms of technological sustainability and energy demand. To date, tape storage remains the most widespread method for data archiving, while DNA data storage appears to offer the best data density and long-term stability in the future. However, DNA data storage is still in its infancy primarily due to economic and accessibility challenges. This emphasizes the need for more practical and readily available alternatives. We present a method for data storage utilizing inkjet printable quantum dots on paper with photoluminescence (PL) readout. Our proof of principle study showcases the ability to print and stack multiple bits of data on a single spot by exploiting the unique PL properties of quantum dots. This approach utilizes easily accessible resources, including a consumer-grade printer and paper as the substrate. Additionally, we perform initial stability tests, investigate scalability by controlling emission intensity, and evaluate the potential data density achievable by our approach.Item type: Item , The relationship between pro-environmental behavior, subjective well-being, and environmental impact: a meta-analysis(2024) Krumm, LauraA substantial change towards more pro-environmental behavior (PEB) is essential to reach the required reduction in greenhouse gas emissions and mitigate climate change. These behavior changes will have consequences on people’s daily lives and thus might affect their well-being. Previous research generally finds positive correlations between PEB and well-being. This meta-analysis explores whether the relationship between PEB and well-being depends on the environmental impact of the performed PEB. Overall, the paper finds a small but significant positive relation between PEB and well-being. When accounting for the environmental impact of the PEB, however, the positive relationship only remains for low-impact PEB. The meta-analysis does not provide any evidence that engaging in high-impact PEB relates to well-being. Consequently, these findings demonstrate that there is more ambiguity in the relationship between PEB and well-being than previously described in the literature and that the environmental impact of PEB matters when evaluating its relationship with well-being. These findings have important implications for policy-making trying to facilitate mitigation efforts that ultimately aim to balance the well-being of the current and future generations.Item type: Item , Design, synthesis and antimycobacterial activity of imidazo[1,5-a]quinolines and their zinc-complexes(2024) Marner, Michael; Kulhanek, Niclas; Eichberg, Johanna; Hardes, Kornelia; Molin, Michael Dal; Rybniker, Jan; Kirchner, Michael; Schäberle, Till F.; Göttlich, RichardTuberculosis has remained one of the world's deadliest infectious diseases. The complexity and numerous adverse effects of current treatment options as well as the emergence of multi-drug resistant M. tuberculosis (Mtb) demand research and innovation efforts to yield new anti-mycobacterial agents. In this study, we synthesized a series of imidazo[1,5-a]quinolines, including 4 new analogs, and evaluated their activity against Mtb. Inspired by previous studies, we also designed 8 compounds featuring a coordinated metal ion, determined their absolute configuration by single-crystal X-ray diffraction and included them in the bioactivity study. Remarkably, the metal complexation of 5c with either Zn2+ or Fe2+ increased the Mtb inhibitory activity of the compound 12.5-fold and reduced its cytotoxicity. Ultimately, out of the 21 analyzed imidazo[1,5-a]quinoline analogs, two zinc complexes (C1 and C7) showed the strongest, specific activity against Mtb H37Rv in vitro (IC90 = 7.7 and 17.7 μM).Item type: Item , The enol of isobutyric acid(2024) Danho, Akkad; Mardyukov, Artur; Schreiner, Peter R.We present the gas-phase synthesis of 2-methyl-prop-1-ene-1,1-diol, an unreported higher energy tautomer of isobutyric acid. The enol was captured in an argon matrix at 3.5 K, characterized spectroscopically and by DFT computations. The enol rearranges likely photochemically to isobutyric acid and dimethylketene. We also identified propene, likely photochemically formed from dimethylketene.Item type: Item , Screening of a-amylase/trypsin inhibitor activity in wheat, spelt and einkorn by high-performance thin-layer chromatography(2024) Müller, Isabel; Schmid, Bianca; Bosa, Loredana; Morlock, Gertrud Elisabethα-Amylase/trypsin inhibitor proteins (ATI) are discussed as possible triggers for non-celiac gluten sensitivity. The potential of high-performance thin-layer chromatography (HPTLC) was studied for the first time to analyse the inhibitory properties of ATIs from flour of wheat, spelt, and einkorn. Inhibition by each flour of the digestive enzymes trypsin or α-amylase was determined by the reduction of released metabolisation products in comparison to non-digested flour, and positive (acarbose) and negative (water) controls. Firstly, amylolysis was carried out in miniaturized form on the HPTLC surface (HPTLC-nanoGIT) after in-vial pre-incubation of the amylase with the inhibitors from flour. α-Amylase inhibition was evident via the reduction of released saccharides, as analysed by normal phase HPTLC. A strong influence of the flour matrix on the assay results (individual saccharides) was evident, caused by an increased amylolysis of further polysaccharides present, making HPTLC analysis more reliable than currently used spectrophotometric sum value assays. The detection and visualization of such matrix influence helps to understand the problems associated with spectrophotometric assays. Only maltotriose was identified as a reliable marker of the amylolysis. The highest α-amylase inhibition and thus the lowest saccharide response was detected for maltotriose in refined spelt, whereas the lowest α-amylase inhibition and thus the highest saccharide response was detected for maltotriose in refined wheat. A comparison of refined and whole grain flours showed no clear trend in the responses. Secondly, trypsin inhibition and proteolysis were performed in-vial, and any inhibition was evident via the reduction of released peptides, analysed by reversed-phase HPTLC. Based on the product pattern of the proteolysis, einkorn and whole wheat showed the highest trypsin inhibition, whereas refined wheat and refined spelt showed the lowest inhibition. Advantageously, HPTLC analysis provided important information on changes in individual saccharides or peptides, which was more reliable and sustainable than spectrophotometric in-vial assays (only sum value) or liquid column chromatography analysis (targeting only the ATI proteins).