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D2.5 Synthesis report on factors influencing dietary behaviour at the micro, meso and macro level
(2024) Joanes, Tina; Candel, Jeroen; Chang, Betty; Devine, Lauren; Elliot, Patrick; Kiel, Tom; Mathijs, Erik; O'Sullivan, Aifric; Reipurth, Malou; Valin, Nina; Vespa, Francesca; Gwozdz, Wencke
Somatic symptom disorder and the role of epistemic trust, personality functioning and child abuse: Results from a population-based representative German sample
(2025) Kampling, Hanna; Riedl, David; Lampe, Astrid; Nolte, Tobias; Brähler, Elmar; Ernst, Mareike; Fegert, Jörg M.; Geisel, Tobias; Hettich-Damm, Nora; Jud, Andreas; Zara, Sandra; Kruse, Johannes
Background: A growing body of evidence explored symptom burden of somatic symptom disorder (SSD) and its complex etiology involving psychosocial aspects. Child abuse has been linked to numerous psychopathologies including somatic symptoms as well as impaired personality functioning and disruptions in epistemic trust. This work aims to investigate personality functioning and epistemic trust in the association between child abuse and somatic symptom burden. Methods: We conducted structural equation modelling (SEM) using representative data of the German population (N = 2436). Personality functioning (OPD-SQS) was applied as a mediator between retrospectively recalled child abuse (ICAST-R) and somatic symptom burden (SSS-8, SSD-12, 6 month time criterion), while epistemic trust was added as a predictor of personality functioning. Results: 6.8 % (n = 166) of participants self-reported SSD. Prevalence of child abuse (53.6 % vs. 31.7 %; χ2 = 33.44, p < .001) was significantly higher among those with SSD. Child abuse was significantly associated with somatic symptom burden (criterion A: β = 0.23, 95 %-CI: 0.19–0.27, p < .001; criterion B (β = 0.24, 95 %-CI: 0.20–0.28, p < .001) and explained 6 % and 5 % of its variance respectively. Adding personality functioning as a mediator increased the explained variance to 28 % for both somatic symptom burden criterion A and B. Including epistemic trust further increased the explained variance of personality functioning (from 15 to 36 %). Limitations: All assessments and results are based on self-report and cross-sectional data. Conclusions: Impairments in personality functioning and disruptions in epistemic trust might play an important role in experiencing symptoms of SSD. Both domains thus present new avenues for treatment improvement and further research in patients with SSD.
A cross-sectional data on women’s empowerment, crop diversification, and nutrition in Benin
(2026-07-08) Akonkwa, Dieu-Merci Nyamuhirwa; Bodjrenou, Fifali Sam Ulrich; Teuber, Ramona
We present cross-sectional data from 558 households in South Benin collected in October 2024. Using a multistage sampling approach, the survey was implemented in three municipalities: Kpomassè, Torri-bossito, and Zè, covering 56 villages. Women were the targeted respondents. We relied on computer-assisted and imagery-assisted personal interviews to collect data on seven modules, including the Abbreviated Women’s Empowerment in Agriculture Index (A-WEAI), household-level crop diversification, and nutrition (dietary diversity, the Food Insecurity Experience Scale, and anthropometric measures). The participants' names, telephone numbers, and geo coordinates were removed to comply with ethics requirements and the informed consent signed by the participants.
Role of lipofibroblasts in alveolar regeneration after viral infection
(2025) Kiliaris, Georgios
As of today, pneumonia induced ARDS has a very high mortality rate with effective treatments being extremely limited. One of the main features of ARDS is the presence of oedema in the airspace of the lung which happens because of the damage inflicted on the tight junctions of the alveolar epithelial cells resulting in the collapse of the alveoli. During homeostasis, it is already known that alveolar fibroblasts 1 (AF1) or lipofibroblasts, are in a very close proximity with the alveolar type 2 (AT2) cells providing them with lipid droplets and therefore supporting them with surfactant production. So, a strong communication between the mesenchyme (AF1 cells) and the alveolar epithelium (AT2 cells) is in effect during homeostatic conditions. Our bulk RNA sequencing data from the mesenchyme of the lung in mock and infected wild type mice (7- and 14-days post infection), showed that the differences in the transcriptomic profile of the 7 d.p.i. mice compared to the control were significant, and between the 14 d.p.i. mice and mock relatively similar, indicating that at 14 d.p.i. the lung was recovering. Importantly, when we looked at the top 100 upregulated genes between days 7 and 14, we noticed several genes associated with AF1 being upregulated 14 d.p.i.. The same genes were also significantly downregulated 7 d.p.i. compared to the mock mice. Following that, we performed a GSEA analysis for the AF1 signature in both day 7 and 14 and that confirmed the loss of AF1 signature 7 d.p.i. and its recovery at 14 d.p.i.. To follow the fate of AF1, we used the Fgf10CreERT2;tdTomatoflox line to lineage trace them and since we have previously shown that metformin can act on the AF1 and have a positive impact on the resolution of bleomycin induced fibrosis in mice, we used metformin as a therapeutic factor. Our data revealed that mice treated with metformin were doing better after infection with significantly less damage present on the lung. We could also observe the loss of the lineage after infection and its restoration after treatment with metformin with the AF1 regaining their lipogenic phenotype. Our single cell RNA sequencing data, also showed us that metformin was able to alter the transcriptomic profile of the lineage traced cells with pathways such as mTOR, cGMP- PKG and AMPK being upregulated and processes such as alveolar development and 59 morphogenesis being enriched. Our results were confirmed in our murine and human PCLS infection model with AF1 markers and, most importantly, AT1 and AT2 markers being upregulated after metformin treatment. Single cell RNA sequencing analysis on the SftpcCre-ERT2;tdTomatoflox lineage traced mice, a line that trace the fate of the AT2 cells, also showed that metformin can accelerate the differentiation of AT2 cells through ADIs to AT1 cells. Integrating the Fgf10Cre-ERT2;tdTomatoflox and SftpcCre-ERT2;tdTomatoflox single cell RNA sequencing data sets, gave us the opportunity to study the dynamics in the intercellular communication between AF1 and AT2. Thus, after performing a comprehensive CellChat analysis, we were able to identify GDF10 and HH as unique pathways of interaction between AF1 and AT2 after treatment with metformin. Quantitative PCR analysis on the murine and human PCLS infection models confirmed the upregulation of GDF10 after treatment with metformin. Also, treating murine PCLS with recombinant GDF10 after infection, showed upregulation of AT1 and AT2 markers further strengthening the idea that GDF10 is important for lung regeneration after influenza-induced lung injury. Importantly, when we studied the human lung cell atlas, we observed a significant downregulation of the AF1 signature and on the expression of GDF10 in the SARS- CoV-2 patients data compared with the donors. The downregulation of GDF10 was also confirmed when we performed in situ hybridization in three different IAV-induced ARDS patients compared to three different donors. With these data, we were able to show the relevance of our murine based results to the human pathological conditions.
Partnership throughout the ages: The coevolution of the transcriptional regulators LEUNIG and SEUSS in the green plant lineage
(2026) Garrecht, Julian Vincent
The LEUNIG (LUG) and SEUSS (SEU) families of transcriptional regulators are centralmodulators of angiosperm development, with relevance lower formation, developmentof male and female gametangia, embryo development, and general plant growth. Theirinteraction forms a regulatory platform, bringing transcription factors and histone mod‐i iers together to both activate and repress target gene expression, thus creating a vastgene regulatory network. Interestingly, both families are deeply conserved, being presentin all land plant lineages and in many streptophyte algae, raising questions about whenthe origin of the LUG – SEU protein module, about their functions outside of angiosperms,and how the module evolved to govern various critical reproductive processes. This dis‐sertation demonstrates that the protein interaction between these two families, and withthe MADS‐box transcription factor family, evolved at least 800 million years ago in thestreptophyte algae, an that LUG and SEU exhibit a strong coevolution ever since. Theyare shown to function as gene regulatory hubs that, among other things, evolved along‐side the MADS‐box proteins to regulate multiple aspects of lower development and an‐giosperm reproduction, in concert with functions in stress response and phytohormonesignaling. Furthermore, the functions of LUG homologs in the moss Physcomitrium patenswere studied, revealing their connections to a critical developmental transition in mosses,and to the regulation of the auxin signaling pathway of land plants.