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Item type:Item, Item type:Item, Item type:Item, Gießener Universitätsblätter 59 (2026)(2026)Enthält u.a.: Prof. Dr. Katharina Lorenz: Wissen schafft Wirklichkeit – Die Universität als Leuchtturm in stürmischen Zeiten. Rede der Präsidentin zum Akademischen Festakt der Justus-Liebig-Universität Gießen am 28. November 2025 Joachim Hendel: Liebig´s Extract. Ein musikalisches Portrait der Justus-Liebig-Universität Gießen: Digitalisierte Tonaufnahmen von Universitätsmusikgruppen aus dem Jahr 1986 Lutz Trautmann: Ein prachtvolles Abzeichen des Rektoramts: Die Gießener Rektorenkette aus dem Jahr 1880 Ghostwriter: Ralf Peveling, Klaus Röder, Gerald Siegmund: Gutenbergstraße 6 – Geschichte eines Hauses in vier Akten Dagmar Klein: Gerichtssaal für Studierende mit Kunst am Bau von 1957 Dagmar Klein: Zur Herkunft des Justus-Liebig-Porträtreliefs auf dem Campus Rechts- und Wirtschaftswissenschaften – Eine Spurensuche Volker Roelcke: Medizin, Kultur und Migration: Manfred Pflanz und die Entstehungsgeschichte eines neuen Arbeitsfelds im Kontext der Universität Gießen Claus Leggewie: Ludwig Börne: Der bekannteste Unbekannte der deutschen Literatur? Eine Würdigung des Kämpfers für Pressefreiheit und Erfinders des politischen Feuilletons Lena Heinstadt, Uli Michael Hennig, Tessa Marquardt, Anna Maria Spittler, Alissa Theiß, Cornelia Weber: Kurzbericht zur Projektförderung der VolkswagenStiftung: „Museumskoffer zur Sammlungs- und Objektforschung − Schwerpunkt Provenienzforschung“ Alexandra Müller: Von Zimmerpflanzen, Bordsteinflechten und urbanen Dschungeln: Naturdarstellungen in der zeitgenössischen Großstadtlyrik Stefan Tebruck: Die Siegelsammlung Theodor Koch-Grünberg Ansgar Kreutzer: „Neues Denken und neue Technologie“: Ein interdisziplinärer Band zur sozial-ökonomischen Transformation Lutz Trautmann: Ein Ehrenpokal für Justus Liebig aus dem Jahr 1851 als Neuzugang in der Silbersammlung der JLU Gießen Silke Bromann: Netzwerken in der Praxis #2 am 28. Oktober 2025: Alumni und Studierende tauschen sich im Faculty Club aus Juliane Dube: Gießener Bilderbuchfestival – Lesung mit Comiczeichnerin Josefine Mark Julian Sorter: Diskurs-Festival 2025: „Foreshocks“ in Gießen vom 6. bis 9. November 2025 Andreas Dittmann: Transborder GeoParks als Instrumente des Environmental Peacebuilding im Südkaukasus Isidora Gazmuri: Karambolage Ana Marija Spasojević, Iryna Tarku: 20. Tagung des Jungen Forums Slavistische Literaturwissenschaft vom 10. bis 12. September 2025 an der JLU Gießen Alona (Olen) Mamai: OVER THE TOPItem type:Item, Impact of allyl-isothiocyanate and high sucrose diet on antimicrobial peptide expression and survival in Drosophila melanogaster(2026) Dähn, Sonja; Zimmermann, Christian; Merschmann, Ronja; Schmutzler, Paul; Wagner, Anika E.The global rise of antibiotic-resistant bacteria highlights the urgent need for alternative strategies to support host defense against infections. Bioactive plant-derived compounds, such as isothiocyanates, have gained attention due to their antimicrobial and immunomodulatory properties. Allyl-isothiocyanate (AITC), a hydrolysis product of glucosinolates found in Brassica vegetables, has demonstrated antimicrobial activity in vitro and the ability to modulate antimicrobial peptide (AMP) expression in cell culture models. However, its in vivo effects under metabolically challenging dietary conditions remain poorly understood. In this study, we investigated the impact of dietary AITC supplementation on immune responses and survival in Drosophila melanogaster exposed to a high-sucrose diet (HSD), a dietary condition known to impair metabolic health and immune function. Flies were fed a HSD with or without 0.25 mM AITC and subsequently subjected to oral infection with either Leuconostoc pseudomesenteroides or Pectobacterium carotovorum subsp. carotovorum, which preferentially activate the Toll and Imd signaling pathways, respectively. AMP expression was analyzed by qPCR and RNA sequencing, and physiological consequences were assessed by performing lifespan analysis. AITC did not affect the flies’ feed intake or basal AMP expression under non-infected conditions. HSD significantly shortened the lifespan in both sexes, and AITC supplementation was not able to rescue this effect. Following oral infection of the flies, both HSD alone and HSD supplemented with AITC influenced the survival in a sex- and pathogen-specific manner, with AITC frequently exacerbating mortality rather than improving outcomes. While selected AMPs, particularly Attacin D, were modulated in a context-dependent manner, RNA sequencing revealed no consistent transcriptional changes in core Toll or Imd pathway components. Overall, our findings indicate that dietary AITC does not enhance host defense in Drosophila melanogaster under high-sugar conditions and that its effects on immunity and survival are strongly sex-specific. These results highlight the complexity of diet–immune interactions and caution against extrapolating in vitro antimicrobial effects to in vivo host protection.Item type:Item, RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices(2026) Mahavadi, Poornima; Korfei, Martina; Müller-Ruttloff, Christin; Ruppert, Clemens; Krauss, Ekaterina; Dorfmüller, Peter; Gattenloehner, Stefan; Dimmeler, Stefanie; El Agha, Elie; Bellusci, Saverio; Herold, Susanne; Witte, Biruta; Ziebuhr, John; Guenther, AndreasBackground: While the renin-angiotensin-aldosterone system (RAAS) is critically involved in pathomechanisms related to SARS-CoV-2 infection, the role of ongoing therapy with angiotensin-converting enzyme 1 inhibitors (ACEi) or Angiotensin-II type 1 receptor (AT1R) blockers (ARB) is much less clear. We evaluated the effects of the ACEi enalapril (ENA) and the ARB losartan (LOS) on SARS-CoV-2 infection in human ex vivo-cultured, precision-cut lung slices (PCLS) obtained from normal human lung tissue. Methods: PCLS were pre-treated for 5d with vehicle, LOS or ENA (300 µM), followed by mock infection or infection with SARS-CoV-2 and incubation with vehicle, LOS or ENA for 1d or 2d. Thereafter, PCLS were harvested for analysis of viral replication, inflammatory responses, endoplasmic reticulum (ER) stress and apoptosis pathways. Results: Both LOS and ENA significantly reduced viral replication in PCLS, with ENA being more potent. LOS was more efficient than ENA in reducing the expression of IL1B, CCL2, CXCL2 and TNFA, but not of IL6, whereas ENA preferentially caused a reduction of IL6 and CCL2 in SARS-CoV-2-infected PCLS. Further, ENA, but not LOS, significantly decreased the expression of viral entry factors, ACE2 and transmembrane serine protease 2 (TMPRSS2), in infected PCLS. Importantly, LOS or ENA did not exert cytotoxic effects. Conclusions: RAAS-antagonizing drugs do not seem to exert detrimental effects during SARS-CoV-2 infection. In opposite, in an ex-vivo model of human PCLS, such treatment was found to dampen SARS-CoV-2 infection and consecutive inflammation.