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Item Microscopy Imaging Data for “Chronic lung disease induced brain microenvironment changes: implications in pre-metastatic niche formation”(2024-09-11) Salik, NazliMicroscopy imaging data related to the “Chronic lung disease induced brain microenvironment changes: implications in pre-metastatic niche formation” manuscript by Salik et al., 2024 Folders (uploaded as zip files): HIF1a and HIF2a IHC (25,08 GB) Podocalyxin and Iba1 staining-FFPE sections (32,79 GB) Podocalyxin-Fibrinogen co-staining (54,15 GB) Representative images (403,81 MB) Videos (28,92 MB) The folders contain image files and corresponding metadata files. Imaging was performed on a CQ1 spinning disc confocal microscope (Yokogawa Life Science, Tokyo, Japan; Cenibra GmbH, Bramsche, Germany) using 405/488/561 nm lasers and 20x, or 40x objective, or on an Axio Scan.Z1 slide scanner (Carl Zeiss Microscopy GmbH, Jena, Germany) using a 20x objective and the ZEN 2.3 software for acquisition. Podocalyxin staining folders contain 4 images that are DAPI, A555 (podocalyxin staining), merge and binary version of podocalyxin staining. Iba1 staining folders contain 5 images that are DAPI, A555 (Iba1 staining), merge, Iba1+ cell count, and DAPI count. Note on Podocalyxin and Iba1 staining - 250um sections: Z-projections are available in the folders as PNG files, original data (>10 Gb for each sample) are available on request. Abbreviations: NO (normoxia): Control Hox (hypoxia): CMH (chronic mild hypoxia) RA (room air): Control SE (smoke exposure) or CS (cigarette smoke): S-PH or S-Em (tobacco-smoke exposure induced pulmonary hypertension or also emphysema, after 3-month or 8-month exposure, respectively)Item Raw Data for best practice study on sustainable insect-based shrimp feeds(2024-08-28) Wilke, Thomas; Barth, AnnalenaThe dataset contains the results of a literature search to identify contributing parameters that may affect life-history parameters of shrimp fed with black soldier fly meal or larvae and the raw data for a best-practice study to assess the effects of black soldier fly feed on life-history and physiological traits of the Pacific white shrimp. The dataset contains five sheets: 1. Summary of 16 publications investigating the use of the black soldier fly as a protein substitute for fishmeal in Pacific white shrimp, 2. Raw data for the controlled trial investigating the effects of fishmeal (FM) and black soldier fly (BSF) based feeds on life-history and physiological traits of Pacific white shrimp, 3. Raw data for an experiment investigating the effects of fishmeal- (FM) and black soldier fly (BSF) based feeds on the contents 18 amino acids (ALA, ARG, ASP, CYS, GLU, GLY, HIS, ILE, LEU, LYS, MET, PHE, PRO, SER, THR, TRP, TYR and VAL) in % dry matter of individual Pacific white shrimp (PWS), 4. Raw data for an experiment investigating the proximate compositions of fishmeal- (FM) based compound feed and black soldier fly (BSF) larvae (DM = dry matter), 5. Raw data for an experiment investigating contents of 18 amino acids (in % dry matter) of a fishmeal- (FM) based diet and black soldier fly (BSF) larvae (DM = dry matter).Item Data for "Imaging the microstructure of lithium and sodium metal in anode-free solid-state batteries using electron backscatter diffraction"(2024-08-28) Fuchs, Till; Ortmann, TillDataset Description: The data set consists of series of measurements of electrochemical impedance spectroscopy, scanning electron microscopy (SEM), and electron backscatter diffraction (EBSD) to characterize the microstructure of lithium and sodium metal as well as electrochemically depositied alkali metals at a solid|solid interfaces. A detailed description of the data set and supplementary information related to the data file formats is provided in the "README" file. The data set presented serves as the basis for the following publication and is structured in accordance with the figures presented in this manuscript: Title: Imaging the Microstructure of Lithium and Sodium Metal in “Anode-Free” Solid-State Batteries using EBSD Authors: Till Fuchs, Till Ortmann, Juri Becker, Catherine G. Haslam, Maya Ziegler, Vipin Kumar Singh, Marcus Rohnke, Boris Mogwitz, Klaus Peppler, Linda F. Nazar, Jeff Sakamoto and Jürgen Janek DOI: Publication Abstract (English): “Anode-free” or more fittingly, metal reservoir-free cells (RFCs) have the potential of drastically improving current solid-state battery technology by achieving higher energy density, improving safety and simplifying the manufacturing process. Various strategies have been reported so far to control the morphology of electrodeposited alkali metal films to be homogeneous and dense, for example, by utilizing planar interfaces with seed interlayers or three-dimensional host structures. To date, the microstructure of such electrodeposited alkali metal, i.e., its grain size distribution, shape and orientation is unknown, and a suitable characterization route is yet to be identified. At the same time, the influence of the alkali metal microstructure on the electrochemical performance of the anode, including the available discharge capacity, is expected to be substantial. Hence, analysis of the microstructure and its influence on the performance of electrochemically deposited alkali metal layers is a key require-ment to improving cell performance. This work establishes first a highly reproducible protocol for characterizing the size and orientation of metal grains in differently processed lithium and sodium samples by a combination of focused-ion beam (FIB) techniques and electron-backscatter diffraction (EBSD) with high spatial resolution. After ruling out grain growth in lithium or sodium during room temperature storage or induced by FIB, electrodeposited films at Cu|LLZO, Steel|LPSCl and Al|NZSP interfaces were then characterized. The analyses show very large grain sizes (>100 µm) within these films and a clear preferential orientation of grain boundaries. Furthermore, metal growth and dissolution were investigated using in situ SEM analyses, showing a dynamic grain coarsening during electrodeposition and pore formation within grains during dissolution. Our methodology and results open up a new research field for the improvement of solid-state battery performance through first characteriza-tion of the deposited alkali metal microstructure and subsequently suggesting methods to control it.Item Data for "Comparative study of gastrointestinal tract size in three parent breeds for the production of dual-purpose organic chickens"(2024) Möller Palau-Ribes, FrancaExcel-Sheet with all measurements of the gastrointestinal tract from three breeds of chicken: White Rock, Bresse Gauloise and New Hampshire. For more details please check publication and contact the corresponding authors.Item Data for "Insight into the Li/LiPON Interface at the Molecular Level: Interfacial Decomposition and Reconfiguration"(2024-05) Wang, Kangli; Mollenhauer, DoreenThis dataset contains the calculated structures involving the surface and interface for the publication: Kangli Wang, Jürgen Janek, Doreen Mollenhauer. "Insight into the Li/LiPON Interface at the Molecular Level: Interfacial Decomposition and Reconfiguration". Further information relevant to the reuse of the dataset can be found in the included readme file.Item Daten zum DFG-Fortsetzungsantrag Open-Access-Publikationskosten 2025-2027(2024) Ruckelshausen, Florian; Arriens, Edda; Dees, Werner; Derichs, Andrea; Freiberg, Michael; Heit, Alexander; Meyer, HelenaDie Daten wurden im Rahmen des DFG-Fortsetzungsantrags Open-Access-Publikationskosten 2025-2027 erhoben. Der Datensatz enthält die im Sinne des Antrags förderfähigen Artikel bzw. Bücher (corresponding author der JLU, Publikationsjahr 2021-2023, DFG-Projektkontext). Eine genaue Beschreibung der Vorgehensweise bei der Erhebung findet sich in der Readme-Datei.Item Experimental Data for "Enhancing the Analysis of Eu3+ Photoluminescence in Coordination Compounds in the Solid State by Determining their Refractive Index"(2024) Sedykh, Alexander E.Normalised excitation and emission spectra, UV-Vis reflectance spectra, powder X-ray diffraction data (Cu-Kalpha radiation), and thermal analysis data of compounds alpha-[Eu(NO3)3(ptpy)(H2O)] (1), beta-[Eu(NO3)3(ptpy)(H2O)] (2), [Eu(NO3)3(ptpy)(acetone)] (3), [Eu(NO3)3(ptpy)(thf)] (4), [Eu(NO3)3(ptpy)(MeOH)] (5), [EuCl3(ptpy)(acetone)] (6), [EuCl3(ptpy)(thf)] (7), and [EuCl3(ptpy)(MeOH)] (8). Files' designation: N_Ex: photoluminescence excitation spectrum of compound N (xy data). N_Em: photoluminescence emission spectrum of compound N (xy data). N_UVVis: UV-Vis reflectance spectrum of compound N (xy data). N_PXRD: powder X-ray diffraction data of compound N (xy data). N_STAMS: simultaneous thermogravimetry and differential thermal analysis coupled with mass-spectrometry (STA-MS) data of compound N (multi-y-column xy data). N_TPXRD: temperature-dependent powder X-ray diffraction data of compound N (multiple xy data).Item Supplemental Material for "Wealth for Health? Affordability of a Healthy and Sustainable Diet - A Food Basket Study"(2024-03) Arendt, SvenjaThis dataset contains Supplemental Material 4 for the publication "Wealth for Health? Affordability of a Healthy and Sustainable Diet – A Food Basket Study" The file provides: - Assessed prices for conventional and organic food products in REWE with product name, price and quantity - Assessed prices for conventional and organic food products in ALDI Süd with product name, price and quantity - Amounts in g/day for the heavy meat consumption diet - Quantities per day and month for the girl in the reference family - Quantities per day and month for the boy in the reference family - Quantities per day and month for the mother in the reference family - Quantities per day and month for the father in the reference family - Amounts in g/day for the moderate meat consumption diet - Quantities per day and month for the girl in the reference family - Quantities per day and month for the boy in the reference family - Quantities per day and month for the mother in the reference family - Quantities per day and month for the father in the reference family - Amounts in g/day for the light meat consumption diet - Quantities per day and month for the girl in the reference family - Quantities per day and month for the boy in the reference family - Quantities per day and month for the mother in the reference family - Quantities per day and month for the father in the reference family - Calculation of total cost and affordabiliy - Calculation of cost shares - Calculation of the share of vegetables and fruits according to the BMEL - Creation of graphs - ReferencesItem Tomography Data - Visualizing the Impact of the Composite Cathode Microstructure and Porosity on Solid-State Battery Performance(2024-03-20) Minnmann, Philip; Schubert, JohannesThe dataset contains tomography data of three composite cathodes (labelled as BM10, BM03, BM01) obtained by FIB-SEM tomography. The dataset contains three subsets: 1. unprocessed SEM images (obtained with the BSE and the SE detector) 2. processed and segmented images 3. Numpy arrays of the tomographies which can be loaded using Python During processing the SEM images were aligned and cropped. Therefore, the dimensions of the segmented tomographies are not identical with those of the raw SEM images. The numpy arrays consist of: 0 - voids 1 - cathode active material 2 - inorganic solid electrolyte 3 - unknown impurity (only for BM01) BM10: Dimensions (774, 900, 790); Phases (0, 1, 2) BM03: Dimensions (713, 850, 413); Phases (0, 1, 2) BM01: Dimensions (681, 1143, 813); Phases (0, 1, 2, 3)Item Data of TiVO2 on TiO2(110)(2024-03-02) Lu, HaoThis data is raw XRD and Raman data of TiVO2 films on TiO2(110). Angle and temperature-dependent Raman spectroscopic measurements were performed using a Renishaw inVia Raman microscope system. Series of Raman spectra in the temperature range between 0 °C and 80 °C were recorded using a Linkam THMS 600 temperature stage. The spectra were taken in backscattering geometry with 514 nm excitation provided by an Ar-ion laser. Excitation and scattered light passed through a long distance objective (50 ×, Olympus, NA = 0.45). The Rayleigh scattered laser light was rejected by an edge filter enabling the measurement of the Stokes Raman scattered light down to 100 cm-1. The laser power on the sample was 1.9 mW and the spot size about 1 µm. Using polarization optics in the beam path allowed us to measure Raman spectra in parallel and crossed polarization configuration of laser and Raman scattered light. Angle-dependent measurements were realized on the same spot on the sample by rotating the polarizer arrangement in the beam path. Angle alpha is between [001] direction of TiO2 substrate and incoming polarization. Angle-dependent Raman measurements were performed at room temperature with Angle alpha from 0 to 360 degrees in 10 degree steps.Angle-dependent Raman measurements were performed at 80 °C with Angle alpha from -90 to 450 degrees in 15 degree steps. X-ray diffraction (XRD) traces Panalytical X'Pert Pro MRD setups using the Cu-Kα line and an additional sample heater to reach temperatures between room temperature and 80 °C. The sample’s electric resistance as a function of temperature was measured by using a linear four-contact geometry and a heater stage. Either tungsten carbide or steel needles with a diameter of 0.5mm were used as contacts. The total force applied to the needles was about 5 to 16 N. The distance between probes was 1 ± 0.01 mm. The resistance measurements were performed in autoranging mode. The heating rate was 2 °C/min.Item Data for "The enol of propionic acid"(2023-08-25) Danho, AkkadIR and UVVis-spectra. A Sumitomo cryostat system consisting of an RDK 408D2 closed-cycle refrigerator cold head and an F-70 compressor unit was used for matrix isolation experiments. A polished CsI window was mounted in the cold head sample holder. The sample holder, connected with silicon diodes for temperature measurements, was covered by a vacuum shroud, which was equipped with KBr windows to allow for IR measurements. In some experiments BaF2 windows were used due to their higher transparency when measuring UV/vis spectra. The sample and the host gas (Ar, purity of 99.999%) were co-deposited at 3.5 K. All spectral data were collected at 3.5 K. The pyrolysis zone was equipped with a heatable 90 mm long quartz tube (inner diameter 7 mm), controlled by a Ni/CrNi thermocouple. The travel distance of the sample from the pyrolysis zone to the matrix was ∼45 mm. Ar was stored in a 2 L gas balloon, which was evacuated and filled three times before every experiment. The sample was evaporated from a Schlenk tube at 70 °C (water) and reduced pressure (∼3 × 10–6 mbar) and co-deposited with a high excess of argon on both sides of the matrix window in the dark (preventing unwanted photochemistry) at a rate of ∼1 mbar min–1, based on the pressure inside the Ar balloon. Pyrolyses were carried out at 500 °C. IR spectra were recorded between 7000 and 350 cm–1 with a resolution of 0.7 cm–1 with a Bruker Vertex 70 FTIR spectrometer. A spectrum of the cold matrix window before deposition was used as background spectrum for the subsequent IR measurements. UV/vis spectra were recorded between 190 and 800 nm with a resolution of 1 nm with a Jasco V-760 spectrophotometer. A high-pressure-mercury lamp equipped with a monochromator (LOT Quantum Design) or a low-pressure-mercury lamp (Gräntzel) fitted with a Vycor filter were used for irradiation of the matrix during photochemical experiments. Spectra were saved as "X-files" and can be opened with "OPUS". Computations. All DFT computations were performed with the Gaussian 16,1 Revision C.01 (full citations for electronic structure codes are given at the end of this document) at the B3LYP/def2-TZVP2-3 level of theory. The keywords Opt and Freq=NoRaman were used for the characterization of minima on the PES. For transition structures the keyword Opt=(ts,tight,calcfc,noeigen) was used. UV/Vis absorptions were computed by using the keyword td(50-50,nstates=10). The results of the calculations were saved as "out" files and can be opened with the editor and graphically with 'ChemCraft'.Item Data for "The Enol of Isobutyric Acid"(2024) Danho, AkkadSpectra for deuterated and non-deuterated enols, along with density functional theory computations IR and UVVis-spectra. A Sumitomo cryostat system consisting of an RDK 408D2 closed-cycle refrigerator cold head and an F-70 compressor unit was used for matrix isolation experiments. A polished CsI window was mounted in the cold head sample holder. The sample holder, connected with silicon diodes for temperature measurements, was covered by a vacuum shroud, which was equipped with KBr windows to allow for IR measurements. In some experiments BaF2 windows were used due to their higher transparency when measuring UV/vis spectra. The sample and the host gas (Ar, purity of 99.999%) were co-deposited at 3.5 K. All spectral data were collected at 3.5 K. The pyrolysis zone was equipped with a heatable 90 mm long quartz tube (inner diameter 7 mm), controlled by a Ni/CrNi thermocouple. The travel distance of the sample from the pyrolysis zone to the matrix was ∼45 mm. Ar was stored in a 2 L gas balloon, which was evacuated and filled three times before every experiment. The sample was evaporated from a Schlenk tube at 80 °C (water) and reduced pressure (∼3 × 10–6 mbar) and co-deposited with a high excess of argon on both sides of the matrix window in the dark (preventing unwanted photochemistry) at a rate of ∼1 mbar min–1, based on the pressure inside the Ar balloon. Pyrolyses were carried out at 750 °C. IR spectra were recorded between 7000 and 350 cm–1 with a resolution of 0.7 cm–1 with a Bruker Vertex 70 FTIR spectrometer. A spectrum of the cold matrix window before deposition was used as background spectrum for the subsequent IR measurements. UV/vis spectra were recorded between 190 and 800 nm with a resolution of 1 nm with a Jasco V-760 spectrophotometer. A high-pressure-mercury lamp equipped with a monochromator (LOT Quantum Design) or a low-pressure-mercury lamp (Gräntzel) fitted with a Vycor filter were used for irradiation of the matrix during photochemical experiments. Spectra were saved as "X-files" and can be opened with "OPUS". Computations. All DFT computations were performed with the Gaussian 16,1 Revision C.01 (full citations for electronic structure codes are given at the end of this document) at the B3LYP/def2-TZVP2-3 level of theory. The keywords Opt and Freq=NoRaman were used for the characterization of minima on the PES. For transition structures the keyword Opt=(ts,tight,calcfc,noeigen) was used. UV/Vis absorptions were computed by using the keyword td(50-50,nstates=10). The results of the calculations were saved as "out" files and can be opened with the editor and graphically with 'ChemCraft'.Item Polymorphism and White Light Emission of 1-Bromo-3,5,7-Triphenyladamantane compared with 1,3,5,7-Tetraphenyladamantane(2024) Saravanan, Gowrisankar; Fokin, Andrey A.; Becker, Jonathan; Mathew, Neeshma; Schmedt auf der Günne, Jörn; Schreiner, Peter RSurprisingly, the crystal structures of bromophenyl adamantanes finely depend on two flavors of London dispersion (LD) interactions: relatively strong CH−π and quite weak Br⋯Br interactions. Here we report our investigation of 1-bromo-3,5,7-triphenyladamantane (1, BrAdPh3) and elucidation of two polymorphic crystal structures denoted as 1A and 1B using single crystal X-ray diffraction (SCXRD). In the monoclinic crystal system of 1A (P21/n space group), we observed CH−π interactions, while Br···Br interactions were absent. Conversely, the Br···Br interactions are a structure-defining factor in the formation of the monoclinic crystal system of 1B (R3 ̅ space group). To provide context, we compare our findings with 1,3,5,7-tetraphenyladamantane (2), characterized by numerous CH−π interactions orchestrating the molecules into chains in the solid. Both CH (phenyl) and CH2 (adamantane) groups thereby participate as dispersion energy donors (DEDs). Computational analyses were employed to investigate the interactions within the characteristic dimers present in the unit cells of 1A and 1B, including visualization of noncovalent interactions and the use of the atoms-in-molecules approach, and molecular orbital analysis. These support the notion of LD dimer-dimer interactions in 1A between the phenyl moieties, whereas 1B exhibits additional dimer-dimer Br···Br contacts. In contrast, the crystals of 2 are exclusively held together by CH−π stacking LD interactions, a feature absent in the polymorphs of 1. Both polymorphic forms of 1 emit white light when subjected to 900 nm continuous wave laser irradiation, displaying a subtle blue shift compared to 2. The absence of CH−π stacking interactions between the dimers of 1 causes a small red-shift in the emission spectrum. The NMR, SCXRD and Computation files are included in this dataset.Item Umfragedaten zur Untersuchung der anwaltlichen Beratungshilfe im Rahmen einer juristischen Dissertation (Befragung von Rechtsanwälten)(2024-02-28) Lefèvre, JuliaDiese Untersuchung wurde als Teil einer Dissertation durchgeführt und richtet sich an Rechtsanwälte in Deutschland, die im Bereich des Zivilrechts tätig sind. Ziel der Studie war es, zu analysieren, inwiefern Rechtsanwälte ihre beruflichen Pflichten gemäß § 49 a Abs. 1 BRAO wahrnehmen. Diese wurden mittels eine Online-Umfrage befragt. Für dessen Erstellung kam die Software LimeSurvey Version 3.23.1+200825 zum Einsatz, bereitgestellt durch eine Lizenz der Justus-Liebig-Universität (JLU). Der Fragebogen, der sowohl offene als auch geschlossene Fragen umfasste, wurde über einen Link auf der LimeSurvey-Plattform zur Verfügung gestellt. Die Auswertung der geschlossenen Fragen erfolgte quantitativ mit der Software IBM SPSS Statistics für Windows, Version 26, wobei deskriptive statistische Analysen durchgeführt wurden. Zwei der im Fragebogen offen gestellten Fragen wurden mittels qualitativer zusammenfassender Inhaltsanalyse unter Verwendung der Software f4analyse (https://www.audiotranskription.de/f4analyse/) analysiert und diese Ergebnisse ergänzend zur deskriptiven statistischen Analyse in die Dissertation aufgenommen. Die Rohdaten der kompletten Umfrage können hier eingesehen werden.Item Histology sections and scanning electron micrographs of floral buds of Pteridophyllum racemosum(2024-02-29) Kong, DoudouThe size of a single photo is about 14MB. The size of a single SEM photo is about 1.25MB. Both SEM graphs and histology sections graphs are formatted as ".TIFF" and can be opened using any image viewer.Item Supplemental Data for "Survey of drug use and its association with herd-level and farm-level characteristics on German dairy farms"(2023-12-13) Abdallah, MiesThe data set contains supplementary tables for paper: "A". This is a voluntary survey of the use of medicines on 50 dairy cow farms in Germany for the year 2020. The tables contain information on the questionnaire used, the farm parameters surveyed, the classification of the regions, the groups of active substances identified, extended information on the statistical tests and the frequencies of the documented diagnoses.Item Code and Data for "S100Z is expressed in a lateral subpopulation of olfactory receptor neurons in the main olfactory system of Xenopus laevis"(2024-02-05) Kahl, Melina; Hassenklöver, ThomasThis repository contains Python scripts that were used to analyze the distribution of manually identified cells in the olfactory system. Multiphoton microscopy image stacks of immunohistochemically labeled olfactory system tissue were manually annotated using the ImageJ ROI Manager tool. Regions of interest were exported from ImageJ as roi-files (provided as zip-archive). We include two datasets that were analyzed using these scripts. The datasets comprise of the imported ROI informations, experiment metadata, and results of calculations performed with the Python scripts. code.py: Script collection to analyze regions of interest drawn using the ImageJ ROI Manager tool. rois_from_imagej.zip: Roi-files exported from ImageJ. Subfolders contain s100z/biocytin labeled cells in different samples. biocytin_cell_counts.csv: Dataset of biocytin-backfilled olfactory receptor neurons s100z_cell_counts.csv: Dataset of human S100Z antibody labeled cellsItem Data for "Development of a multi‐step screening procedure for redox active molecules in organic radical polymer anodes and as redox flow anolytes"(2024-01) Achazi, Andreas J.; Mollenhauer, DoreenCalculated structural data of organic redox compounds for the publication: Andreas J. Achazi, Xhesilda Fataj, Philip Rohland, Martin D. Hager, Ulrich S. Schubert, Doreen Mollenhauer. "Development of a multi‐step screening procedure for redox active molecules in organic radical polymer anodes and as redox flow anolytes". The structures were optimized at different levels of theory. After downloading and unpacking the *zip-file you will find a file named "Readme.pdf" which contains all details on how to use the dataset and additional computational information to recalculate all data from the dataset (information about software etc.).Item Data for "3D micro printed capillary electrospray thruster with a fully modular integrated extraction electrode"(2023-11-08) Kunze, FynnVideos and the correlating extraction data from 3D micro printed electrospray thrusters. Multiple videos taken from in-situ observation of extraction. Some videos were cut from the live footage captured or slowed/speed up for visibility reasons. However, no further modification were done. For more information read the README file.Item Supplemental Data for "Genetic evaluations and genome-wide association studies for specific digital dermatitis diagnoses in dairy cows considering genotype x housing system interactions"(2023-12-13) Sölzer, Niklas; Yin, TongThe present study aimed to use detailed phenotyping for the claw disorder digital dermatitis (DD) considering specific DD stages in two housing systems (conventional cubicle barns = CON and compost bedded pack barns = CBPB) to infer possible genotype x housing system interactions. The DD-stages included 2,980 observations for the three traits DD-sick, DD-acute and DD-chronic from 1,311 Holstein-Friesian and 399 Fleckvieh-Simmental cows. Selection of the 5 CBPB and 5 CON herds was based on a specific protocol to achieve a high level of herd similarity with regard to climate, feeding, milking system and location, but with pronounced housing system differences. Five other farms had “a mixed system” with two sub-herds, one representing CBPB and the other one CON. 899 cows (1530 observations) represented the CBPB system, and 811 cows (1450 observations) the CON system. The average disease prevalence was 20.47 % for DD-sick, 13.88 % for DD-acute and 5.34 % for DD-chronic, with a higher prevalence in CON than in CBPB. After quality control of 50K genotypes, 38,495 SNPs from 926 cows remained for the ongoing genomic analyses.