# Supplemental Tables for "Associations between days in the close-up group and milk production, transition cow diseases, reproductive performance, culling and behavior, around calving of Holstein dairy cows"

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## Zusammenfassung

The objective of the study was to evaluate the association between days in the close-up group (DINCU) and milk production, early lactation diseases, reproductive performance, culling risk and behaviour around calving. In this investigation 14 different statistical models were calculated to evaluate the association between days in the close-up group (DINCU) and 305-d milk projection of nulliparous (1) and parous (2) cows; between DINCU and the risk for clinical hypocalcemia of parous cows (3); between DINCU and the risk for hyperketonemia of nulliparous (4) and parous (5) cows; between DINCU and the risk for displaced abomasum of parous cows (6); between DINCU and the risk for retained placenta of nulliparous (7) and parous (8) cows, between DINCU and the risk for acute puerperal metritis of nulliparous (9) and parous cows (10); between DINCU and the risk for mastitis in parous cows (11); between DINCU and first service pregnancy risk (12); and between DINCU and culling risk of nulliparous (13) and parous (14) cows.

Supplemental Table S1 displays the final linear mixed model evaluating the association between days in the close-up group and predicted 305-d milk projection based on 2nd test day milk production of nulliparous cows (n = 7,985).

Supplemental Table S2 displays the final linear mixed model evaluating the association between days in the close-up group and predicted 305-d milk projection based on 2nd test day milk production of parous cows (n = 17,483).

Supplemental Table S3 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and predicted risk of clinical hypocalcemia of parous cows (n = 19,641).

Supplemental Table S4 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of hyperketonemia (ß-hydroxybutyrate ≥ 1.2 mmol/L using a cow-side blood BHB test) of nulliparous cows (n = 8,798).

Supplemental Table S5 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of hyperketonemia (ß-hydroxybutyrate ≥ 1.2 mmol/L using a cow-side blood BHB test) of parous cows (n = 19,641).

Supplemental Table S6 displays the final multivariable logistic regression model evaluating the association between days in the close-up group (DINCU) and the predicted risk for left displaced abomasum using least square estimates (mean ± SEM) from the generalized linear mixed model of parous cows (n = 19,641).

Supplemental Table S7 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of retained placenta of nulliparous cows (n = 8,798).

Supplemental Table S8 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of retained placenta of parous cows (n = 19,641).

Supplemental Table S9 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of acute puerperal metritis of nulliparous cows (n = 8,798).

Supplemental Table S10 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk of acute puerperal metritis of parous cows (n = 19,641).

Supplemental Table S11 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and the predicted risk for mastitis within 30 DIM of parous cows (n = 19,641).

Supplemental Table S12 displays the final multivariable logistic regression model evaluating the association between days in the close-up group and first service pregnancy risk of parous cows (n = 19,641).

Supplemental Table S13 displays the final Cox proportional hazards model evaluating the association between days in the close-up group and predicted probability of culling until 300 DIM in nulliparous cows (n = 8,798).

Supplemental Table S14 displays the final Cox proportional hazards model evaluating the association between days in the close-up group and predicted probability of culling until 300 DIM in parous cows (n = 19,641).