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Item type: Item , Data for "Ozone-tolerant rice for air-polluted environments"(2025-11-14) Alam, Muhammad Shahedul; Frei, MichaelDescription of dataset This dataset provides data from a project aimed at breeding of ozone tolerant rice lines. The lines were developed by introgressing previously reported ozone tolerance QTL (Frei et al. 2008) into the Bangladeshi elite rice varieties BINA dhan11 and BRRI dhan 28. The genetic markers and genotypes of the resulting lines are documented in the file ‘Sequence and Genotyping’. The different lines were then tested in a greenhouse experiment and field experiment (ozone concentrations, see file ‘Ozone data’). The remaining files present physiological and morphological data of the different breeding lines under control and high ozone conditions. Abbreviations O3 = ozone ppm = parts per million ppb = parts per billion KASP = Kompetitive Allele-Specific PCR LBS = leaf bronzing score NDVI = normalized difference vegetation index Lic2 = Lichtenthaler index 2 (representing carotenoid/chlorophyll ratio) SC = stomatal conductance PhiPS2 = Quantum efficiency of photosystem 2 of light adapted leaves A = CO2 assimilation rate MDA = malondialdehyde References - Frei M, Tanaka JP, Wissuwa M (2008) Genotypic variation in tolerance to elevated ozone in rice: dissection of distinct genetic factors linked to tolerance mechanisms. Journal of Experimental Botany 59, 3741-3752. - Alam MA, Islam MM, Do MK, Osimahon BO, Karki AK, Baburajan AI, Hartung M, Autarmat S, Feng Y, Wissuwa M, Frei M (2025) Ozone-tolerant rice for air-polluted environments. Global Change Biology, in press.Item type: Item , The EPPO/OLAF compendium of national procedures: Croatia(2025) Hauck, Pierre; Schneider, Jan-MartinThis Croatian EPPO/OLAF volume discusses the Croatian laws relevant to European Public Prosecutor's Office (EPPO) investigations of EU fraud in Croatia. It covers EPPO procedures in Croatia, practical examples, EU fraud typologies, criminological findings and relevant case law. The volume also introduces criminal financial law in fraud cases and discusses the key defenses that must be protected in EPPO proceedings. The second part summarizes the provisions governing OLAF investigations in Croatia, with a focus on external investigations under Regulation 2020/2223.Item type: Item , Different Treatment Outcomes of Multiple Sclerosis Patients Receiving Ocrelizumab or Ofatumumab(2025) Meuth, Sven G.; Wolff, Stephanie; Mück, Anna; Willison, Alice; Kleinschnitz, Konstanze; Räuber, Saskia; Pawlitzki, Marc; Konen, Franz Felix; Skripuletz, Thomas; Grothe, Matthias; Ruck, Tobias; Huttner, Hagen B.; Kleinschnitz, Christoph; Bopp, Tobias; Pul, Refik; Cree, Bruce A. C.; Hartung, Hans-Peter; Möllenhoff, Kathrin; Pfeuffer, SteffenObjective: B-cell–depletion via CD20 antibodies is a safe and effective treatment for active relapsing multiple sclerosis (RMS). Both ocrelizumab (OCR) and ofatumumab (OFA) have demonstrated efficacy in randomized controlled trials and are approved for treatment of RMS, yet nothing is known on their comparative effectiveness, especially in the real-world setting. Methods: This prospective cohort study includes patients that were started on either OCR or OFA between September 2021 and December 2023. Patients were followed until June 2024 and recruited at 3 large tertiary centers in Germany (Duesseldorf, Essen, and Giessen). Propensity-score-matching was used to address baseline imbalances among patients. Clinical relapses, presence of new or enlarging MRI lesions and 6-month confirmed disability worsening were evaluated. Non-inferiority of OFA compared to OCR was evaluated through comparison of Kaplan–Meier-estimates. Results: A total of 1,138 patients were initially enrolled in the cohort. Following patient selection and propensity-score-matching, 544 OCR and 417 OFA patients were included in the final analysis. In our primary analysis, OFA was non-inferior to OCR in terms of relapses, disability progression, and accrual of MRI lesions. Subgroup analyses confirmed findings in previously naïve and platform-treated patients. Potential differences between OFA and OCR were seen in patients switching from S1P receptor modulators or natalizumab. Conclusion: We here provide comparative data on the effectiveness of OCR and OFA in patients with active RMS. OFA was non-inferior to OCR in the overall cohort. Potential differences observed in patients switching from S1P receptor modulators or natalizumab require further validation.Item type: Item , Individual Shrimp Rearing Increases the Power of Experimental Trials(2025) Wilke, Thomas; Bendag, Slim; Barth, Annalena; Reinold, Tim; Schubert, PatrickComparable and reproducible research is needed to improve Pacific white shrimp (PWS) aquaculture. These experiments typically involve before-and-after measurements of the same individual for paired statistical testing. However, marking shrimp with external or internal tags is challenging, especially for juveniles. A possible alternative is to rear shrimp individually in single-shrimp systems. While such systems may also prevent competitive interactions, PWS are considered social animals and individual rearing may negatively affect social behavior. Therefore, the general goal of this study was to evaluate the effects of single-shrimp versus multi-shrimp systems on the survival, growth, and welfare of juvenile PWS using a randomized controlled trial with group sizes of one, three, and five individuals. We found that shrimp kept individually had a higher survival rate, higher final body weights and lengths, and longer antennae than shrimp kept in groups of three or five. The incidence of eye cataracts was not significantly different among groups. Based on these results, we conclude that the individual rearing of juvenile PWS has no negative effects on survival, growth, or welfare. Therefore, a single-shrimp system could be an alternative to individually marked shrimp to allow paired statistical testing in experimental trials, especially when using post-larvae or juvenile specimens.Item type: Item , Multi-Stage Reconstructive Surgery of the Eyeball with No Light Perception After Severe Open Globe Injury(2025) Lytvynchuk, Lyubomyr; Ponomarov, Makar; Carlos Reyna, Erick; Stieger, Knut; Andrassi-Darida, MonikaPurpose: To analyze the visual and anatomical outcomes of multi-stage reconstructive surgery of the eyeball with no light perception (NLP) in patients after severe open globe injury (OGI). Patients and methods: In this retrospective consecutive case series study, medical records of patients with severe OGI with visual loss up to NLP, who were referred to our clinic between February 1, 2016, and March 30, 2021, were included. The analysis of epidemiologic data, type and severity of OGI, timing and type of surgical treatment, and anatomical and functional results was performed. Results: Nine patients met our inclusion criteria. The mean age was 52 years (range 34– 78 years). Mean follow-up was 24 months (range 1– 56 months). Estimated mean best corrected visual acuity (BCVA) was 2.92 LogMAR immediate after trauma, 2.27 LogMAR before reconstructive anterior segment surgery and 2.42 LogMAR at last follow-up. The functional gain after the primary repair was highly significant (p 0.005), but a non-significant gain was seen at the last follow-up. Retina reattachment was achieved in most of the cases (6/7, 85.7%), but these remained silicone oil dependent (5/6, 83.33%). In all cases, it was possible to prevent primary enucleation. Conclusion: The multi-stage reconstructive surgical approach allowed for saving the eyes and improved the functional and anatomical condition. Despite the severity of OGI and NLP, an early surgical intervention should be considered by experienced surgeons.