• Policy
    • FAQ JLUdocs
    • FAQ JLUdata
    • Publishing in JLUdocs
    • Publishing in JLUdata
    • Publishing Contract
    • English
    • Deutsch
View Item 
  •   JLUpub Home
  • JLUdocs
  • Dissertationen/Habilitationen
  • View Item
  •   JLUpub Home
  • JLUdocs
  • Dissertationen/Habilitationen
  • View Item
  • Info
    • Policy
    • FAQ JLUdocs
    • FAQ JLUdata
    • Publishing in JLUdocs
    • Publishing in JLUdata
    • Publishing Contract
  • English 
    • English
    • Deutsch
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Proteomic biomarkers of azoospermia in seminal plasma and testicular interstitial fluid

Thumbnail
Files in this item
Sgaier Raouda- 2022-05-02.pdf (8.017Mb)
Date
2021-11-10
Author
Sgaier, Raouda
Advisors/Reviewers
Diener, Martin
Metadata
Show full item record
BibTeX Export
Quotable link
http://dx.doi.org/10.22029/jlupub-1129
Abstract

Azoospermia, which manifests as the absence of sperm in the semen, is a prevalent form of male infertility, affecting 10-15% of infertile men. Assisted reproductive techniques (ARTs) represent an excellent therapeutic option for azoospermic men, allowing infertile couples to achieve pregnancy. Microsurgical TEsticular Sperm Extraction (micro-TESE) ... is a surgical technique that allows for the extraction of spermatozoa from any active spermatogenesis pockets in the testis, even in patients with severe testicular failure. The extracted spermatozoa can subsequently be used in ICSI or IVF procedures. Men with normal or quantitatively diminished spermatogenesis (obstructive azoospermia or hypospermatogenesis diagnosis), have better chances for the success of sperm extraction, whereas spermatogenic arrest (SA) or the total loss of germ cells, known as Sertoli cell only syndrome (SCO) means the retrieval of any sperm viable for fertilization is unlikely, lowering the clinical benefit of such procedures. Current clinical tests used for the differential diagnosis of azoospermia are insufficient without a histological examination of testicular tissue. Testicular biopsy, or alternatively an exploratory TESE, remains the golden standard in the diagnosis of idiopathic male infertility. Novel biomarkers that can accurately predict the outcome of sperm extraction, and that are measurable in semen or in blood plasma would represent an ideal, non-invasive alternative. Deep analysis of seminal plasma, the acellular fraction of semen, and of testicular interstitial fluid (TIF), the biological fluid surrounding seminiferous tubules with access to the bloodstream, can also offer new insights into the etiology of azoospermia and the cellular processes involved in testicular function.

Comment

Joint PhD from Monash University in Melbourne, Australia and Justus-Liebig University (JLU) in Giessen, Germany

Collections
  • Dissertationen/Habilitationen
CC0 1.0 Universal
CC0 1.0 Universal

Contact Us | Impressum | Privacy Policy | OAI-PMH
 

 

Browse

All of JLUpubCommunities & CollectionsOrganisational UnitDDC-ClassificationPublication TypeAuthorsBy Issue DateThis CollectionOrganisational UnitDDC-ClassificationPublication TypeAuthorsBy Issue Date

My Account

LoginRegister

Statistics

View Usage Statistics

Contact Us | Impressum | Privacy Policy | OAI-PMH