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dc.contributor.authorOffner, Thomas
dc.contributor.authorWeiss, Lukas
dc.contributor.authorDaume, Daniela
dc.contributor.authorBerk, Anna
dc.contributor.authorInderthal, Tim Justin
dc.contributor.authorManzini, Ivan
dc.contributor.authorHassenklöver, Thomas
dc.date.accessioned2023-09-14T10:20:21Z
dc.date.available2023-09-14T10:20:21Z
dc.date.issued2023
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/18465
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-17829
dc.description.abstractGlomeruli are the functional units of the vertebrate olfactory bulb (OB) connecting olfactory receptor neuron (ORN) axons and mitral/tufted cell (MTC) dendrites. In amphibians, these two circuit elements regularly branch and innervate multiple, spatially distinct glomeruli. Using functional multiphoton-microscopy and single-cell tracing, we investigate the impact of this wiring on glomerular module organization and odor representations on multiple levels of the Xenopus laevis OB network. The glomerular odor map to amino acid odorants is neither stereotypic between animals nor chemotopically organized. Among the morphologically heterogeneous group of uni- and multi-glomerular MTCs, MTCs can selectively innervate glomeruli formed by axonal branches of individual ORNs. We conclude that odor map heterogeneity is caused by the coexistence of different intermingled glomerular modules. This demonstrates that organization of the amphibian main olfactory system is not strictly based on uni-glomerular connectivity.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64
dc.language.isoen
dc.rightsNamensnennung 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddcddc:570
dc.titleFunctional odor map heterogeneity is based on multifaceted glomerular connectivity in larval Xenopus olfactory bulb
dc.typearticle
local.affiliationFB 08 - Biologie und Chemie
local.projectgrant 4113/4-1
local.source.spage1
local.source.epage27
local.source.journaltitleiScience
local.source.volume26
local.source.number9
local.source.articlenumber107518
local.source.urihttps://doi.org/10.1016/j.isci.2023.107518


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