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dc.contributor.authorGalli, Matteo
dc.contributor.authorJacob, Stefan
dc.contributor.authorZheng, Ying
dc.contributor.authorGhezellou, Parviz
dc.contributor.authorGand, Martin
dc.contributor.authorAlbuquerque, Wendell
dc.contributor.authorImani, Jafargholi
dc.contributor.authorAllasia, Valérie
dc.contributor.authorCoustau, Christine
dc.contributor.authorSpengler, Bernhard
dc.contributor.authorKeller, Harald
dc.contributor.authorThines, Eckhard
dc.contributor.authorKogel, Karl-Heinz
dc.date.accessioned2024-02-07T15:08:19Z
dc.date.available2024-02-07T15:08:19Z
dc.date.issued2023
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/19002
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-18363
dc.description.abstractMacrophage migration inhibitory factor (MIF) is a pleiotropic protein with chemotactic, pro-inflammatory, and growth-promoting activities first discovered in mammals. In parasites, MIF homologs are involved in immune evasion and pathogenesis. Here, we present the first comprehensive analysis of an MIF protein from the devastating plant pathogen Magnaporthe oryzae (Mo). The fungal genome encodes a single MIF protein (MoMIF1) that, unlike the human homolog, harbors multiple low-complexity regions (LCRs) and is unique to Ascomycota. Following infection, MoMIF1 is expressed in the biotrophic phase of the fungus, and is strongly down-regulated during subsequent necrotrophic growth in leaves and roots. We show that MoMIF1 is secreted during plant infection, affects the production of the mycotoxin tenuazonic acid and inhibits plant cell death. Our results suggest that MoMIF1 is a novel key regulator of fungal virulence that maintains the balance between biotrophy and necrotrophy during the different phases of fungal infection.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64
dc.language.isoen
dc.rightsNamensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddcddc:630
dc.titleMIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae
dc.typearticle
local.affiliationFB 09 - Agrarwissenschaften, Ökotrophologie und Umweltmanagement
local.projectKo 1208/25-1 (KHK) and ANR-16-CE92-0014-01; INST 162/500-1 FUGG
local.source.spage1
local.source.epage17
local.source.journaltitleiScience
local.source.volume26
local.source.articlenumber107565
local.source.urihttps://doi.org/10.1016/j.isci.2023.107565


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