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dc.contributor.authorMatés, José M.
dc.contributor.authorDi Paola, Floriana J.
dc.contributor.authorCampos-Sandoval, José A.
dc.contributor.authorMazurek, Sybille
dc.contributor.authorMárquez, Javier
dc.date.accessioned2021-10-14T05:56:31Z
dc.date.available2021-10-14T05:56:31Z
dc.date.issued2019-05-22
dc.identifier.urihttps://doi.org/10.1016/j.semcdb.2019.05.012
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/291
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-238
dc.description.abstractMetabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a signaling molecule involved in essential pathways regulated by oncogenes and tumor suppressor factors. Glutaminase isoenzymes are critical proteins to control glutaminolysis, a key metabolic pathway for cell proliferation and survival that directs neoplasms’ fate. Adaptive glutamine metabolism can be altered by different metabolic therapies, including the use of specific allosteric inhibitors of glutaminase that can evoke synergistic effects for the therapy of cancer patients. We also review other clinical applications of in vivo assessment of glutaminolysis by metabolomic approaches, including diagnosis and monitoring of cancer.de_DE
dc.description.sponsorshipEUde_DE
dc.language.isoende_DE
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGlutaminolysisde_DE
dc.subject.ddcddc:570de_DE
dc.titleTherapeutic targeting of glutaminolysis as an essential strategy to combat cancerde_DE
dc.typearticlede_DE
local.affiliationFB 10 - Veterinärmedizinde_DE
local.projectFördernummer 722605, TRANSMITde_DE
local.source.spage34de_DE
local.source.epage43de_DE
local.source.journaltitleSeminars in Cell & Developmental Biologyde_DE
local.source.volume98de_DE


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