Show simple item record

dc.contributor.advisorSeeger, Werner
dc.contributor.advisorDammann, Reinhard
dc.contributor.advisorSchlüter, Klaus-Dieter
dc.contributor.advisorKönig, Peter
dc.contributor.authorPérez Bravo, David
dc.date.accessioned2022-11-10T12:04:15Z
dc.date.available2022-11-10T12:04:15Z
dc.date.issued2022
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/7968
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-7384
dc.description.abstractUnderstanding the process of alveolarization is necessary, since it is key to develop new therapeutic strategies for pulmonary structural diseases. Unfortunately, in vivo approaches in mice often lead to lethal phenotypes and there are strong ethical concerns in the way of in vivo human studies of alveolarization. Therefore, the development of a suitable in vitro model to study alveolarization emerges as an attractive and indeed necessary alternative. The present study is aimed to characterize and validate current models of precision cut lung slices (PCLS) in postnatal mice to identify the best possible conditions to objectively validate structural changes upon in vitro alveolarization using stereology.de_DE
dc.language.isoende_DE
dc.rightsIn Copyright*
dc.rights.urihttp://rightsstatements.org/page/InC/1.0/*
dc.subject.ddcddc:570de_DE
dc.titleCharacterization and validation of postnatal murine precision cut lung slices using different approaches of stereologyde_DE
dc.typedoctoralThesisde_DE
dcterms.dateAccepted2022-09-07
local.affiliationFB 11 - Medizinde_DE
thesis.levelthesis.doctoralde_DE


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright