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dc.contributor.authorEuler, Gerhild
dc.date.accessioned2022-11-18T09:51:00Z
dc.date.available2016-02-25T12:57:52Z
dc.date.available2022-11-18T09:51:00Z
dc.date.issued2015
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-119696
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9172
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-8560
dc.description.abstractMyocardial infarction is a prevailing cause of death in industrial countries. In spite of the good opportunities we have nowadays in interventional cardiology to reopen the clotted coronary arteries for reperfusion of ischemic areas, post-infarct remodeling emerges and contributes to unfavorable structural conversion processes in the myocardium, finally resulting in heart failure. The growth factor TGFß is upregulated during these processes. In this review, an overview on the functional role of TGFß signaling in the process of cardiac remodeling is given, as it can influence apoptosis, fibrosis and hypertrophy thereby predominantly aggravating ischemia/reperfusion injury.en
dc.language.isoende_DE
dc.rightsNamensnennung 3.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectmyocardial infarctionen
dc.subjecttransforming growth factor betaen
dc.subjectSMADen
dc.subjectmicroRNAen
dc.subjecthypertrophyen
dc.subject.ddcddc:610de_DE
dc.titleGood and bad sides of TGFbeta-signaling in myocardial infarctionen
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.id11969
local.opus.instituteInstitute of Physiologyde_DE
local.opus.fachgebietMedizinde_DE
local.source.urihttps://doi.org/10.3389/fphys.2015.00006
local.source.freetextFrontiers in Physiology 6:66de_DE


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