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dc.contributor.authorSeni, Jeremiah
dc.contributor.authorFalgenhauer, Linda
dc.contributor.authorSimeo, Nabina
dc.contributor.authorMirambo, Mariam M.
dc.contributor.authorImirzalioglu, Can
dc.contributor.authorMatee, Mecky
dc.contributor.authorRweyemamu, Mark
dc.contributor.authorChakraborty, Trinad
dc.contributor.authorMshana, Stephen E.
dc.date.accessioned2022-11-18T09:51:26Z
dc.date.available2016-12-23T13:38:46Z
dc.date.available2022-11-18T09:51:26Z
dc.date.issued2016
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-124060
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9234
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-8622
dc.description.abstractThe increased presence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in humans, animals, and their surrounding environments is of global concern. Currently there is limited information on ESBL presence in rural farming communities worldwide. We performed a cross-sectional study in Mwanza, Tanzania, involving 600 companion and domestic farm animals between August/September 2014. Rectal swab/cloaca specimens were processed to identify ESBL-producing Enterobacteriaceae. We detected 130 (21.7%) animals carrying ESBL-producing bacteria, the highest carriage being among dogs and pigs [39.2% (51/130) and 33.1% (43/130), respectively]. The majority of isolates were Escherichia coli [93.3% (125/134)] and exotic breed type [OR (95%CI) = 2.372 (1.460 3.854), p-value < 0.001] was found to be a predictor of ESBL carriage among animals. Whole-genome sequences of 25 ESBL-producing E. coli were analyzed for phylogenetic relationships using multi-locus sequence typing (MLST) and core genome comparisons. Fourteen different sequence types were detected of which ST617 (7/25), ST2852 (3/25), ST1303 (3/25) were the most abundant. All isolates harbored the blaCTX-M-15 allele, 22/25 carried strA and strB, 12/25 aac(6)-lb-cr, and 11/25 qnrS1. Antibiotic resistance was associated with IncF, IncY, as well as non-typable plasmids. Eleven isolates carried pPGRT46-related plasmids, previously reported from isolates in Nigeria. Five isolates had plasmids exhibiting 85 99% homology to pCA28, previously detected in isolates from the US. Our findings indicate a pan-species distribution of ESBL-producing E. coli clonal groups in farming communities and provide evidence for plasmids harboring antibiotic resistances of regional and international impact.en
dc.language.isoende_DE
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectfarming communitiesen
dc.subjectcompanion animalsen
dc.subjectdomestic farm animalsen
dc.subjectESBLen
dc.subjectMwanza Tanzaniaen
dc.subject.ddcddc:570de_DE
dc.titleMultiple ESBL-producing Escherichia coli sequence types carrying quinolone and aminoglycoside resistance genes circulating in companion and domestic farm animals in Mwanza, Tanzania, harbor commonly occurring plasmidsen
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.id12406
local.opus.instituteInstitute of Medical Microbiologyde_DE
local.opus.fachgebietMedizinde_DE
local.source.urihttps://doi.org/10.3389/fmicb.2016.00142
local.source.freetextFrontiers in Microbiology 7:142de_DE


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