Show simple item record

dc.contributor.authorSimons, Viktor S.
dc.contributor.authorLochnit, Guenter
dc.contributor.authorWilhelm, Jochen
dc.contributor.authorIshaque, Bernd
dc.contributor.authorRickert, Markus
dc.contributor.authorSteinmeyer, Jürgen
dc.date.accessioned2022-11-18T09:54:23Z
dc.date.available2019-10-22T10:08:23Z
dc.date.available2022-11-18T09:54:23Z
dc.date.issued2018
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-148981
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9505
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-8893
dc.description.abstractCollagen hydrolysates (CHs) are heterogeneous mixtures of collagen peptides that are often used as nutraceuticals for osteoarthritis (OA). In this study, we compared the peptide composition and pharmacological effects of three different CH preparations (CH-Alpha((R)), Peptan((R)) B 2000 and Mobiforte((R))) as well as their production batches. Our biochemical analysis using MALDI-TOF mass spectrometry and the ICPL-isotope labelling method revealed marked differences between different CH preparations and even between some production batches of the same preparation. We also investigated the pharmacological effects of these CHs on human fibroblast-like synoviocytes (FLS). No significant effects on cultured FLS could be demonstrated for either production batch of CH-Alpha((R)), Peptan((R)) B 2000, and Mobiforte((R)) analyzing a small number of pharmacological relevant targets. Thus, our study already shows for the first time that different production batches of the same CH preparation as well as different CH preparations can differ significantly in their peptide composition. In this line, further studies are also needed to verify equal pharmacological efficacy of CH batches on a much broader range of (patho)physiological relevant targets. If OA patients are to be offered a safe and effective nutraceutical a better knowledge about all potential effects as well as ensuring the same active-substance levels are a prerequisite.en
dc.language.isoende_DE
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddcddc:610de_DE
dc.titleComparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytesen
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.id14898
local.opus.instituteLaboratory for Experimental Orthopaedics, Department of Orthopaedicsde_DE
local.opus.fachgebietMedizinde_DE
local.source.urihttps://doi.org/10.1038/s41598-018-36046-3
local.source.freetextScientific Reports 8:17733de_DE


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record