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dc.contributor.authorTomasovic, Ana
dc.contributor.authorTraub, Stephanie
dc.contributor.authorTikkanen, Ritva
dc.date.accessioned2022-11-18T09:56:14Z
dc.date.available2012-01-09T08:46:41Z
dc.date.available2022-11-18T09:56:14Z
dc.date.issued2012
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-85611
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9623
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-9011
dc.description.abstractFibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases. During signal transduction, FRS2 can be both tyrosine and threonine phosphorylated and forms signaling complexes with other adaptor proteins and tyrosine phosphatases. We have here identified flotillin-1 and the cbl-associated protein/ponsin (CAP) as novel interaction partners of FRS2. Flotillin-1 binds to the phosphotyrosine binding domain (PTB) of FRS2 and competes for the binding with the fibroblast growth factor receptor. Flotillin-1 knockdown results in increased Tyr phosphorylation of FRS2, in line with the inhibition of ERK activity in the absence of flotillin-1. CAP directly interacts with FRS2 by means of its sorbin homology (SoHo) domain, which has previously been shown to interact with flotillin-1. In addition, the third SH3 domain in CAP binds to FRS2. Due to the overlapping binding domains, CAP and flotillin-1 appear to compete for the binding to FRS2. Thus, our results reveal a novel signaling network containing FRS2, CAP and flotillin-1, whose successive interactions are most likely required to regulate receptor tyrosine kinase signaling, especially the mitogen activated protein kinase pathway.de_DE
dc.language.isoende_DE
dc.rightsNamensnennung 3.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectFGF signallingen
dc.subjectFlotillin-1en
dc.subjectFibroblast growth factor receptor substrate 2 (FRS2)en
dc.subjectcbl-associated protein/ponsin (CAP)en
dc.subjectsignal transductionen
dc.subject.ddcddc:570de_DE
dc.titleMolecular networks in FGF signaling : Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2de_DE
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.id8561
local.opus.instituteInstitute of Biochemistryde_DE
local.opus.fachgebietMedizinde_DE
local.source.urihttps://doi.org/10.1371/journal.pone.0029739
local.source.freetextPLoS ONE, 7(1), e29739de_DE


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