Biotechnology-enhanced genetic controls of the global pest Drosophila suzukii

Abstract

Spotted wing Drosophila (Drosophila suzukii Matsumura, or SWD), an insect pest of soft-skinned fruits native to East Asia, has rapidly spread worldwide in the past 15 years. Genetic controls such as sterile insect technique (SIT) have been considered for the environmentally friendly and cost-effective management of this pest. In this review, we provide the latest developments for the genetic control strategies of SWD, including sperm-marking strains, CRISPR-based sex-ratio distortion, neoclassical genetic sexing strains, transgenic sexing strains, a sex-sorting incompatible male system, precision-guided SIT, and gene drives based on synthetic Maternal effect dominant embryonic arrest (Medea) or homing CRISPR systems. These strategies could either enhance the efficacy of traditional SIT or serve as standalone methods for the sustainable control of SWD.