Acute response of biomarkers in plasma from capillary blood after a strenuous endurance exercise bout

dc.contributor.authorReichel, Thomas
dc.contributor.authorHeld, Steffen
dc.contributor.authorSchwarz, Anthony
dc.contributor.authorHacker, Sebastian
dc.contributor.authorWesemann, Fabian
dc.contributor.authorDonath, Lars
dc.contributor.authorKrüger, Karsten
dc.date.accessioned2023-12-11T12:31:45Z
dc.date.available2023-12-11T12:31:45Z
dc.date.issued2023
dc.description.abstractPurpose: The present study aims to investigate the acute response of potential exercise-sensitive biomarkers in capillary plasma to an acute incremental running test. In a second step, their concentration was compared to the changes in the venous serum. Methods: Thirty-seven active young female and male adults completed a VO2max ramp test on a treadmill. Before and after exercise, capillary blood from the earlobe and venous blood were taken and synchronized. Concentrations of Interleukin- (IL-) 1β, IL-1ra, IL-6, IL-8, IL-17A, Interferon (IFN)-y, CC-chemokine ligand (CCL)-2, Matrix metallopeptidase (MMP)- 9, Secreted protein acidic and rich in cysteine (SPARC), Cluster of differentiation (CD)163, S100 Ca2+ -binding protein (S100) A8, S100A9, S100B, Brain-derived neurotrophic factor (BDNF), and Myeloperoxidase (MPO) were determined by magnetic bead-based multiplex assay. Results: Capillary plasma concentrations of IL-1β, IL-6, IL-8, IL-17A, IFN-y, CCL-2, MMP-9, SPARC, CD163, S100A9, S100B, and BDNF increased after exercise (p < 0.05). Comparing the values from capillary plasma and venous serum, ICCs classified as good were found for IFN-y (post), while the ICCs for IL-1β, IL-8, IL-17A, CCL-2, MMP-9 (post), SPARC, and BDNF (post) were classified as moderate. For all other parameters, only weak ICCs were found. Conclusion: As in the venous serum, there was an increase in most markers in the capillary plasma. However, acceptable to low associations can be found in the concentration levels of these proteins between the compartments. Thus, this source of blood sampling could find some biomarker applications in sports practice.
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/18804
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-18168
dc.language.isoen
dc.rightsNamensnennung 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddcddc:796
dc.titleAcute response of biomarkers in plasma from capillary blood after a strenuous endurance exercise bout
dc.typearticle
local.affiliationFB 06 - Psychologie und Sportwissenschaft
local.source.epage189
local.source.journaltitleEuropean journal of applied physiology
local.source.spage179
local.source.urihttps://doi.org/10.1007/s00421-022-05068-1
local.source.volume123

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