Eine neue Funktion für HIF: die Umstellung des Metabolismus im Zellzyklus
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Abstract
The family of hypoxia-inducible transcription factors (HIF) is typically activated by low oxygen concentrations. We observed a transient increase of the HIF-1α protein levels during the G1 phase of the cell cycle, designated as G1-HIF. This cell cycle-regulated form of HIF ensures cell proliferation and survival under conditions of metabolic stress by increasing the levels of key metabolites during the cell cycle. The generation of G1-HIF depends on an AMPK-mediated signaling pathway.Link to publications or other datasets
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Biospektrum 30 (2024), 755 - 759