Identification of the G-protein Gn-Alpha-11 and of the zinc transporter ZIP9 as key components in the mediation of non-classical signaling cascades of androgenic steroids
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Abstract
In addition to the so-called classical action of steroid hormones (SH) via intracellularly localized steroid hormone receptors (SHRs), SH can also induce signalling by so-called non-classical pathways, thought to be mediated through receptors on the plasma membrane. Neither the range of the signaling events nor the corresponding receptors involved in the fast signalling of the non-classical signaling pathways of SH have been characterized or even identified yet. In order to complete current knowledge concerning the action of androgenic steroids and to further understand their actions and physiological relevance for cells of the male reproductive system it is crucial to characterize possible signaling events mediated through them and to identify the receptor types they are interacting with. Thus the focus of the investigation presented here was placed on the actions of two androgens that are abundant in the male gonads, dehydroepiandrosterone sulfate (DHEAS) and the testosterone.Link to publications or other datasets
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Giessen : VVB Laufersweiler Verlag