Site-Selective Acylation of Pyranosides with Immobilized Oligopeptide Catalysts in Flow
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Abstract
We report the site-selective acetylation of partially protected monosaccharides using immobilized oligopeptide catalysts, which are readily accessible via solid-phase peptide synthesis. The catalysts are able to invert the intrinsic selectivity, which was determined using N-methylimidazole, for a variety of pyranosides. We demonstrate that the catalysts are stable for multiple reaction cycles and can be easily reused after separation from the reaction solution. The catalysts can also be used in flow without loss of reactivity and selectivity.Link to publications or other datasets
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Chemistry - a European journal 29 (2023), e202203002